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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-7-28
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pubmed:abstractText |
Beta-defensins are broad-spectrum antimicrobial peptides (APs) that are components of innate immunity. Recent investigations showed the induction of beta-defensins in synovial membranes of osteoarthritic (OA) joints and suggested that they have functions other than the ability to kill microbes. As a result of these findings, we undertook this study to investigate the production of human beta-defensin 3 (HBD-3) in OA cartilage and to determine its influence on chondrocyte function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1736-45
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pubmed:dateRevised |
2008-9-8
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pubmed:meshHeading |
pubmed-meshheading:15934078-Adult,
pubmed-meshheading:15934078-Aged,
pubmed-meshheading:15934078-Animals,
pubmed-meshheading:15934078-Cartilage, Articular,
pubmed-meshheading:15934078-Cells, Cultured,
pubmed-meshheading:15934078-Chondrocytes,
pubmed-meshheading:15934078-Humans,
pubmed-meshheading:15934078-Metalloproteases,
pubmed-meshheading:15934078-Mice,
pubmed-meshheading:15934078-Middle Aged,
pubmed-meshheading:15934078-Osteoarthritis, Knee,
pubmed-meshheading:15934078-Synovial Membrane,
pubmed-meshheading:15934078-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:15934078-beta-Defensins
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pubmed:year |
2005
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pubmed:articleTitle |
Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors.
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pubmed:affiliation |
University Hospital Schleswig-Holstein, Campus Kiel, Germany. d.varoga@orthop.uni-kiel.de
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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