| pubmed-article:15929722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0766823 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0972255 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0042971 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0025543 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0333275 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C1511603 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:15929722 | lifeskim:mentions | umls-concept:C0244730 | lld:lifeskim |
| pubmed-article:15929722 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:15929722 | pubmed:dateCreated | 2005-9-21 | lld:pubmed |
| pubmed-article:15929722 | pubmed:abstractText | The cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A was shown to inhibit collagen-stimulated platelet aggregation and to interact with MG-63 osteosarcoma cells via integrin alpha2beta1 to inhibit adhesion to collagen I. In addition, we demonstrate by solid-phase binding assays that atrolysin A binds to collagen I and to vWF (von Willebrand factor) via exosites in the cysteine-rich domain. Interestingly, the binding site of the cysteine-rich domain on collagen I is distinct from the cell adhesion site, since the incubation of collagen-I-coated plates with the cysteine-rich domain did not prevent the adhesion of MG-63 cells to collagen. Finally, we show by surface plasmon resonance (BIAcore) analyses that the cysteine-rich domain can block vWF binding to collagen I as well as the binding of collagen I to vWF. Taken together, these results indicate that this domain may function as a cell-surface-receptor-binding site and/or a substrate recognition exosite and may thus play a role in the pathologies associated with atrolysin A. | lld:pubmed |
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| pubmed-article:15929722 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15929722 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15929722 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15929722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15929722 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15929722 | pubmed:issn | 1470-8728 | lld:pubmed |
| pubmed-article:15929722 | pubmed:author | pubmed-author:FoxJay WJW | lld:pubmed |
| pubmed-article:15929722 | pubmed:author | pubmed-author:ShannonJohn... | lld:pubmed |
| pubmed-article:15929722 | pubmed:author | pubmed-author:SerranoSolang... | lld:pubmed |
| pubmed-article:15929722 | pubmed:author | pubmed-author:JiaLi-GuoLG | lld:pubmed |
| pubmed-article:15929722 | pubmed:author | pubmed-author:WangDeyuD | lld:pubmed |
| pubmed-article:15929722 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15929722 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15929722 | pubmed:volume | 391 | lld:pubmed |
| pubmed-article:15929722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15929722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15929722 | pubmed:pagination | 69-76 | lld:pubmed |
| pubmed-article:15929722 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:meshHeading | pubmed-meshheading:15929722... | lld:pubmed |
| pubmed-article:15929722 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15929722 | pubmed:articleTitle | Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor. | lld:pubmed |
