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rdf:type |
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lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0014898,
umls-concept:C0132800,
umls-concept:C0205198,
umls-concept:C0220781,
umls-concept:C0596902,
umls-concept:C0599682,
umls-concept:C0871161,
umls-concept:C1167622,
umls-concept:C1611588,
umls-concept:C1883254
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pubmed:issue |
11
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pubmed:dateCreated |
2005-5-26
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pubmed:abstractText |
3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters (8a-h) showed high affinity for the norepinephrine transporter (NET). The most potent and selective compound was 3alpha-(3-fluoro-4-methylphenyl)nortropane-2beta-carboxylic acid methyl ester (8d), with a Ki of 0.43 nM at the NET and 21- and 55-fold selectivity relative to binding at the dopamine and serotonin transporters. The development of 8d makes available compounds selective for all three transporters from the same structural class.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3852-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15916437-Animals,
pubmed-meshheading:15916437-Binding, Competitive,
pubmed-meshheading:15916437-Brain,
pubmed-meshheading:15916437-Cocaine,
pubmed-meshheading:15916437-Dopamine,
pubmed-meshheading:15916437-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:15916437-Male,
pubmed-meshheading:15916437-Membrane Glycoproteins,
pubmed-meshheading:15916437-Membrane Transport Proteins,
pubmed-meshheading:15916437-Nerve Tissue Proteins,
pubmed-meshheading:15916437-Norepinephrine,
pubmed-meshheading:15916437-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:15916437-Radioligand Assay,
pubmed-meshheading:15916437-Rats,
pubmed-meshheading:15916437-Rats, Sprague-Dawley,
pubmed-meshheading:15916437-Serotonin,
pubmed-meshheading:15916437-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:15916437-Structure-Activity Relationship,
pubmed-meshheading:15916437-Symporters
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.
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pubmed:affiliation |
Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA. fic@rti.org
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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