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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-8-3
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pubmed:abstractText |
Prostate cancer (PRCA) is the most common cancer in males in the western world. In Finland PRCA has an age-adjusted incidence of 81.5 per 100,000. We previously reported that in Finland, the late-onset cases in families with "no-male-to-male" (NMM) transmission of PRCA accounted for most of the linkage to the HPCX region (Xq27-28). The aim of the present study was to test for linkage disequilibrium (LD) and haplotype-sharing around marker DXS1205 between cases from hereditary prostate cancer (HPC) families and population controls. The initial allelic association was performed between 108 PRCA cases and 257 population controls genotyped for 23 markers in the Xq26-28 region. This resulted in a highly significant nominal one-sided Fisher's exact P-value of 0.0003 for allele ''180'' of marker DXS1205. Subsequently, a similar level of significance was observed for the same allele for marker DXS1205 (P=0.0002) when comparing 60 NMM cases and 257 controls. These results were still significant after Bonferroni correction for multiple testing. Fine mapping efforts included the genotyping of four additional markers D3S2390, bG82i1.9, bG82i1.1, bG82i1.0 and four single nucleotide polymorphisms (SNPs) to augment the original markers around DXS1205.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0340-6717
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pubmed:author |
pubmed-author:Baffoe-BonnieAgnes BAB,
pubmed-author:Bailey-WilsonJoan EJE,
pubmed-author:BalshemAndrew MAM,
pubmed-author:CarptenJohn DJD,
pubmed-author:GillandersElizabeth MEM,
pubmed-author:IsaacsWilliam BWB,
pubmed-author:KainuTommiT,
pubmed-author:KallioniemiOlli-POP,
pubmed-author:MatikainenMikaM,
pubmed-author:ScarboroughSheehan DSD,
pubmed-author:SchleutkerJohannaJ,
pubmed-author:SmithJeffrey RJR,
pubmed-author:SoodRamanR,
pubmed-author:StephanDietrich ADA,
pubmed-author:TammelaTeuvoT,
pubmed-author:TeslovichTanya MTM,
pubmed-author:TrentJeffrey MJM,
pubmed-author:XuJianfengJ
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15906096-Chromosome Mapping,
pubmed-meshheading:15906096-Chromosomes, Human, X,
pubmed-meshheading:15906096-DNA Mutational Analysis,
pubmed-meshheading:15906096-Finland,
pubmed-meshheading:15906096-Gene Frequency,
pubmed-meshheading:15906096-Genetic Markers,
pubmed-meshheading:15906096-Genetic Predisposition to Disease,
pubmed-meshheading:15906096-Genotype,
pubmed-meshheading:15906096-Haplotypes,
pubmed-meshheading:15906096-Humans,
pubmed-meshheading:15906096-Linkage Disequilibrium,
pubmed-meshheading:15906096-Male,
pubmed-meshheading:15906096-Neoplasm Proteins,
pubmed-meshheading:15906096-Nuclear Proteins,
pubmed-meshheading:15906096-Prostatic Neoplasms,
pubmed-meshheading:15906096-Sequence Analysis, DNA,
pubmed-meshheading:15906096-Tumor Suppressor Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region.
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pubmed:affiliation |
Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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