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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa(3)DTPA) in a dose of 34.7 micromol kg(-1) as a function of its route of administration was investigated in rats with a puncture wound contaminated by (90)Y-chloride at a concentration of 2.55 MBq kg(-1). Approximately 60% of (90)Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in femoral bone increased during the timed-release of (90)Y. Intravenous administration of CaNa(3)DTPA (systemic treatment) at 15 min post-puncture reduced (90)Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNa(3)DTPA into a puncture wound site (local treatment) at 15 min post-puncture diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing (90)Y from a puncture wound and minimising (90)Y-distribution to bone compared with systemic treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0144-8420
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-13
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pubmed:meshHeading |
pubmed-meshheading:15899907-Animals,
pubmed-meshheading:15899907-Body Burden,
pubmed-meshheading:15899907-Chelating Agents,
pubmed-meshheading:15899907-Decontamination,
pubmed-meshheading:15899907-Female,
pubmed-meshheading:15899907-Injections,
pubmed-meshheading:15899907-Metabolic Clearance Rate,
pubmed-meshheading:15899907-Pentetic Acid,
pubmed-meshheading:15899907-Radiation Dosage,
pubmed-meshheading:15899907-Radiation Injuries,
pubmed-meshheading:15899907-Radiation-Protective Agents,
pubmed-meshheading:15899907-Rats,
pubmed-meshheading:15899907-Rats, Wistar,
pubmed-meshheading:15899907-Relative Biological Effectiveness,
pubmed-meshheading:15899907-Tissue Distribution,
pubmed-meshheading:15899907-Treatment Outcome,
pubmed-meshheading:15899907-Wounds, Penetrating,
pubmed-meshheading:15899907-Yttrium
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pubmed:year |
2005
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pubmed:articleTitle |
Effect of calcium trisodium DTPA in rats with puncture wound contaminated by 90Y-chloride.
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pubmed:affiliation |
Department of Medical Imaging, National Institute of Radiological Sciences, Chiba 263-8555, Japan. N.Watanabe@iaea.org
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pubmed:publicationType |
Journal Article
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