Source:http://linkedlifedata.com/resource/pubmed/id/15899409
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2005-5-18
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pubmed:abstractText |
We studied whether complement receptor (CR) mediated Mycobacterium avium interaction modulated macrophage TNF-alpha expression. Compared to control conditions, infections performed with C3-depletion yielded significantly higher TNF-alpha levels. Blockage of the CR4 iC3b site yielded increases in TNF-alpha for all morphotypic variants of a virulent serovar-8 strain (smooth transparent (SmT), smooth opaque (SmO), serovar-specific glycopeptidolipid (ssGPL) deficient knockout mutant) whereas CR3 blockage increased TNF-alpha only for SmT and ssGPL-deficient strains. Thus, complement-mediated binding of M. avium to CR3 and CR4 was shown to modulate TNF-alpha expression. The differential activation of morphotypic and isogenic variants of a single strain provides an excellent model system to delineate signaling pathways.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Complement C3,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C4,
http://linkedlifedata.com/resource/pubmed/chemical/Glycolipids,
http://linkedlifedata.com/resource/pubmed/chemical/Glycopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0378-1097
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
246
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15899409-Animals,
pubmed-meshheading:15899409-Cell Line,
pubmed-meshheading:15899409-Complement C3,
pubmed-meshheading:15899409-Complement C4,
pubmed-meshheading:15899409-Glycolipids,
pubmed-meshheading:15899409-Glycopeptides,
pubmed-meshheading:15899409-Humans,
pubmed-meshheading:15899409-Macrophages,
pubmed-meshheading:15899409-Mice,
pubmed-meshheading:15899409-Mycobacterium avium Complex,
pubmed-meshheading:15899409-Mycobacterium avium-intracellulare Infection,
pubmed-meshheading:15899409-Receptors, Complement,
pubmed-meshheading:15899409-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Induction of murine macrophage TNF-alpha synthesis by Mycobacterium avium is modulated through complement-dependent interaction via complement receptors 3 and 4 in relation to M. avium glycopeptidolipid.
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pubmed:affiliation |
Division of Infectious Diseases, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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