Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-13
pubmed:abstractText
Myelin-associated glycoprotein (MAG) contributes to the prevention of axonal regeneration in the adult central nervous system (CNS). However, changes in MAG expression following lesions and the involvement of MAG in the failure of cortical connections to regenerate are still poorly understood. Here, we show that MAG expression is differently regulated in the entorhinal cortex (EC) and the hippocampus in response to axotomy of the perforant pathway. In the EC, MAG mRNA is transiently overexpressed by mature oligodendrocytes after lesion. In the hippocampus, MAG overexpression is accompanied by an increase in the number of MAG-expressing cells. Lastly, the participation of MAG in preventing axonal regeneration was tested in vitro, where neuraminidase treatment of axotomized entorhino-hippocampal cultures potentiates axonal regeneration. These results demonstrate that MAG expression is regulated in response to cortical axotomy, and indicate that it may limit axonal regeneration after CNS injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1044-7431
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15896979-Animals, pubmed-meshheading:15896979-Animals, Newborn, pubmed-meshheading:15896979-Axons, pubmed-meshheading:15896979-Axotomy, pubmed-meshheading:15896979-Cell Communication, pubmed-meshheading:15896979-Coculture Techniques, pubmed-meshheading:15896979-Entorhinal Cortex, pubmed-meshheading:15896979-Gene Expression Regulation, pubmed-meshheading:15896979-Growth Inhibitors, pubmed-meshheading:15896979-Hippocampus, pubmed-meshheading:15896979-Mice, pubmed-meshheading:15896979-Myelin-Associated Glycoprotein, pubmed-meshheading:15896979-Nerve Regeneration, pubmed-meshheading:15896979-Neuraminidase, pubmed-meshheading:15896979-Oligodendroglia, pubmed-meshheading:15896979-Organ Culture Techniques, pubmed-meshheading:15896979-Perforant Pathway, pubmed-meshheading:15896979-RNA, Messenger, pubmed-meshheading:15896979-Up-Regulation
pubmed:year
2005
pubmed:articleTitle
Overexpression of myelin-associated glycoprotein after axotomy of the perforant pathway.
pubmed:affiliation
Development and Regeneration of the CNS, Cellular Biology Department, Barcelona Science Park-IRB, University of Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't