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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-10
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pubmed:abstractText |
Growth plate chondrocytes up-regulate calcium-sensing receptor (CaR) expression as they mature to hypertrophy. In cells other than chondrocytes, extracellular calcium-sensing via the CaR functions partly to promote expression of parathyroid hormone-related protein (PTHrP), a critical regulator of endochondral development. Moreover, PTHrP is up-regulated in human osteoarthritis (OA) and surgically induced rabbit OA cartilages and may promote both chondrocyte proliferation and osteophyte formation therein. Hence, we examined chondrocyte CaR-mediated calcium-sensing in OA pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1063-4584
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
395-404
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15882563-Animals,
pubmed-meshheading:15882563-Cartilage, Articular,
pubmed-meshheading:15882563-Cattle,
pubmed-meshheading:15882563-Cells, Cultured,
pubmed-meshheading:15882563-Chondrocytes,
pubmed-meshheading:15882563-Collagenases,
pubmed-meshheading:15882563-Guinea Pigs,
pubmed-meshheading:15882563-Hindlimb,
pubmed-meshheading:15882563-Immunohistochemistry,
pubmed-meshheading:15882563-Male,
pubmed-meshheading:15882563-Matrix Metalloproteinase 13,
pubmed-meshheading:15882563-Osteoarthritis,
pubmed-meshheading:15882563-Parathyroid Hormone-Related Protein,
pubmed-meshheading:15882563-Receptors, Calcium-Sensing,
pubmed-meshheading:15882563-Receptors, Parathyroid Hormone,
pubmed-meshheading:15882563-Tissue Inhibitor of Metalloproteinase-3,
pubmed-meshheading:15882563-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression.
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pubmed:affiliation |
San Diego Veterans Administration Healthcare System, San Diego, CA 92161, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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