|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-6-16
|
|
pubmed:abstractText |
Mutations/polymorphisms in the CARD15/NOD2 gene and in the promoter region of the TNFalpha gene are associated with susceptibility to and modulate the phenotype of Crohn's disease (CD). The molecular mechanisms for this genotype-phenotype correlation are yet to be elucidated. CARD15 is an intracellular receptor for bacterial muramyl dipeptide (MDP), and can elicit an inflammatory response via activation of the NF-kappaB pathway. MDP is also known to induce the expression of pro-inflammatory cytokines including TNFalpha, through a still poorly characterized signaling pathway. We sought to determine whether CARD15-mediated NF-kappaB activation can contribute to MDP-induced TNFalpha production and, consequently, if polymorphisms in both genes affect the control of such induction.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0179-1958
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
305-11
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15800781-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:15800781-Adjuvants, Immunologic,
pubmed-meshheading:15800781-Cell Culture Techniques,
pubmed-meshheading:15800781-Crohn Disease,
pubmed-meshheading:15800781-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:15800781-Genetic Predisposition to Disease,
pubmed-meshheading:15800781-Genotype,
pubmed-meshheading:15800781-Humans,
pubmed-meshheading:15800781-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15800781-Kidney,
pubmed-meshheading:15800781-NF-kappa B,
pubmed-meshheading:15800781-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:15800781-Phenotype,
pubmed-meshheading:15800781-Polymorphism, Genetic,
pubmed-meshheading:15800781-Promoter Regions, Genetic,
pubmed-meshheading:15800781-Transcription, Genetic,
pubmed-meshheading:15800781-Transfection,
pubmed-meshheading:15800781-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms.
|
|
pubmed:affiliation |
Microbiology and Tumor Biology Center, Karolinska Institute, Nobels Vag 16, 17177, Stockholm, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
