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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0017262,
umls-concept:C0030956,
umls-concept:C0044602,
umls-concept:C0079784,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0206116,
umls-concept:C0596290,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2005-3-28
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pubmed:abstractText |
Alzheimer's disease is characterized by numerous amyloid-beta peptide (Abeta) plaques surrounded by microglia. Here we report that Abeta induces the proliferation of the mouse microglial cell line Ra2 by increasing the expression of macrophage colony-stimulating factor (M-CSF). We examined signal cascades for Abeta-induced M-CSF mRNA expression. The induction of M-CSF was blocked by a phosphatidylinositol 3 kinase (PI3-kinase) inhibitor (LY294002), a Src family tyrosine kinase inhibitor (PP1) and an Akt inhibitor. Electrophoretic mobility shift assays showed that Abeta enhanced NF-kappaB binding activity to the NF-kappaB site of the mouse M-CSF promoter, which was blocked by LY294002. These results indicate that Abeta induces M-CSF mRNA expression via the PI3-kinase/Akt/NF-kappaB pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/4-amino-5-(4-methylphenyl)-7-(tert-b...,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/amyloid beta-protein (25-35),
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
579
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1995-2000
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15792809-Amyloid beta-Peptides,
pubmed-meshheading:15792809-Animals,
pubmed-meshheading:15792809-Cell Proliferation,
pubmed-meshheading:15792809-Cells, Cultured,
pubmed-meshheading:15792809-Chromones,
pubmed-meshheading:15792809-Gene Expression,
pubmed-meshheading:15792809-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15792809-Mice,
pubmed-meshheading:15792809-Microglia,
pubmed-meshheading:15792809-Morpholines,
pubmed-meshheading:15792809-Peptide Fragments,
pubmed-meshheading:15792809-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15792809-Protein Kinase Inhibitors,
pubmed-meshheading:15792809-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15792809-Proto-Oncogene Proteins,
pubmed-meshheading:15792809-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15792809-Pyrazoles,
pubmed-meshheading:15792809-Pyrimidines,
pubmed-meshheading:15792809-RNA, Messenger,
pubmed-meshheading:15792809-Signal Transduction,
pubmed-meshheading:15792809-src-Family Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells.
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pubmed:affiliation |
Department of Basic Gerontology, National Institute for Longevity Sciences, 36-3 Gengo, Morioka-cho, Obu, Aichi 474-8522, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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