Source:http://linkedlifedata.com/resource/pubmed/id/15767330
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-3-15
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| pubmed:abstractText |
Extracellular matrix-degrading matrix metalloproteinase-1 (MMP-1) is an interstitial collagenase that degrades the interstitial types I, II, and III collagens, and overexpression of MMP-1 is associated with cancer development and cellular invasion. The 2G allele of the MMP-1 -1607 1G/2G polymorphism is associated with enhanced transcriptional activity. We investigated the association between the MMP-1 1G/2G polymorphism and lung cancer risk in 1,752 Caucasian lung cancer patients and 1,363 healthy controls. There were no overall associations between the MMP-1 genotypes and risk of lung cancer, with the adjusted odds ratios of 1.15 [95% confidence interval (CI), 0.94-1.40] for the 1G/2G genotype and 1.14 (95% CI, 0.90-1.45) for the 2G/2G genotype, when versus the 1G/1G genotype. Stratified analyses suggested higher lung cancer risk for the 2G allele in never-smokers and males, with the adjusted odds ratios of 1.67 (95% CI, 1.02-2.76; 1G/2G) and 1.50 (95% CI, 0.86-2.62; 2G/2G) in never-smokers; and 1.30 (95% CI, 1.00-1.75; 1G/2G) and 1.23 (95% CI, 0.88-1.73; 2G/2G) in males, respectively. In conclusion, genotypes containing the 2G allele of the MMP-1 polymorphism are associated with higher risk of lung cancer in never-smokers and in males.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
1055-9965
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
567-70
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15767330-Adult,
pubmed-meshheading:15767330-Aged,
pubmed-meshheading:15767330-Aged, 80 and over,
pubmed-meshheading:15767330-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15767330-Carcinoma, Small Cell,
pubmed-meshheading:15767330-Case-Control Studies,
pubmed-meshheading:15767330-Female,
pubmed-meshheading:15767330-Genotype,
pubmed-meshheading:15767330-Humans,
pubmed-meshheading:15767330-Lung Neoplasms,
pubmed-meshheading:15767330-Male,
pubmed-meshheading:15767330-Matrix Metalloproteinase 1,
pubmed-meshheading:15767330-Middle Aged,
pubmed-meshheading:15767330-Odds Ratio,
pubmed-meshheading:15767330-Polymorphism, Genetic,
pubmed-meshheading:15767330-Promoter Regions, Genetic,
pubmed-meshheading:15767330-Risk Factors,
pubmed-meshheading:15767330-Smoking
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Matrix metalloproteinase-1 promoter polymorphism and lung cancer risk.
|
| pubmed:affiliation |
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|