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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025124,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0040300,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0228174,
umls-concept:C0441889,
umls-concept:C1681221,
umls-concept:C2911684
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-3-14
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pubmed:abstractText |
The molecular mechanism of the Chinese traditional medicine 'Bushen Yinao Pian' (a complex prescription used for clinical anti-ageing in China for over 20 years) is elusive. In this study, the cDNA of low-density lipoprotein related-receptor associated protein-1 (LRPAP-1), an ageing-related gene, which functions as a chaperon or escort protein in the intracellular transport of low-density lipoprotein related-receptor, a transporter of amyloid beta protein (AbetaP), had been cloned by screening cDNA library based on analyzing the gene expression in cerebral tissue between the test and the control accelerated senescence-prone mouse 8/Ta (SAMP8/Ta). The result shows that this complex prescription increased the expression level of LRPAP-1. It indicated that the Chinese traditional medicine 'Bushen Yinao Pian' plays an important role in anti-ageing by increasing LRPAP-1 expression level.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0378-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15763364-Administration, Oral,
pubmed-meshheading:15763364-Aging, Premature,
pubmed-meshheading:15763364-Animals,
pubmed-meshheading:15763364-Brain Diseases,
pubmed-meshheading:15763364-Cloning, Molecular,
pubmed-meshheading:15763364-Disease Models, Animal,
pubmed-meshheading:15763364-Drug Evaluation, Preclinical,
pubmed-meshheading:15763364-Drugs, Chinese Herbal,
pubmed-meshheading:15763364-Gene Expression,
pubmed-meshheading:15763364-Gene Library,
pubmed-meshheading:15763364-LDL-Receptor Related Protein-Associated Protein,
pubmed-meshheading:15763364-Male,
pubmed-meshheading:15763364-Medicine, Chinese Traditional,
pubmed-meshheading:15763364-Mice,
pubmed-meshheading:15763364-Mice, Mutant Strains,
pubmed-meshheading:15763364-Molecular Chaperones,
pubmed-meshheading:15763364-Plant Preparations,
pubmed-meshheading:15763364-Plants, Medicinal,
pubmed-meshheading:15763364-RNA, Messenger,
pubmed-meshheading:15763364-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2005
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pubmed:articleTitle |
The Chinese traditional medicine 'Bushen Yinao Pian' increased the level of ageing-related gene LRPAP-1 expression in the cerebral tissue of accelerated senescence-prone mouse 8/Ta.
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pubmed:affiliation |
The Institute of Genetics and Developmental Biology, Chinese Academy of sciences, P.O. Box 2707, Beijing 100080, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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