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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-3-9
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pubmed:abstractText |
The androgen receptor (AR) is a ligand-dependent transcription factor that mediates gene expression and growth of normal and malignant prostate cells. In prostate tumors that recur after androgen withdrawal, the AR is highly expressed and transcriptionally active in the absence of testicular androgens. In these "androgen-independent" tumors, alternative means of AR activation have been invoked, including regulation by growth factors and their receptors in prostate cancer recurrence.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1704-12
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pubmed:dateRevised |
2010-10-6
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pubmed:meshHeading |
pubmed-meshheading:15755991-Genes, Reporter,
pubmed-meshheading:15755991-Genes, erbB-2,
pubmed-meshheading:15755991-Humans,
pubmed-meshheading:15755991-Male,
pubmed-meshheading:15755991-Neuregulin-1,
pubmed-meshheading:15755991-Phosphorylation,
pubmed-meshheading:15755991-Prostatic Neoplasms,
pubmed-meshheading:15755991-Receptor, erbB-2,
pubmed-meshheading:15755991-Receptor, erbB-3,
pubmed-meshheading:15755991-Receptors, Androgen,
pubmed-meshheading:15755991-Recurrence,
pubmed-meshheading:15755991-Signal Transduction,
pubmed-meshheading:15755991-Transcriptional Activation,
pubmed-meshheading:15755991-Tumor Cells, Cultured,
pubmed-meshheading:15755991-Tyrosine
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pubmed:year |
2005
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pubmed:articleTitle |
Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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