Source:http://linkedlifedata.com/resource/pubmed/id/15746436
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown. To test the hypothesis that CD40L expressed on hematopoietic cell types (eg, macrophages, lymphocytes, platelets) is crucial to atherogenesis, we performed bone marrow reconstitution experiments using low-density receptor-deficient (ldlr-/-) and ldlr-/-/cd40l-/- compound-mutant mice.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4636
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1244-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15746436-Animals,
pubmed-meshheading:15746436-Aorta, Abdominal,
pubmed-meshheading:15746436-Atherosclerosis,
pubmed-meshheading:15746436-Bone Marrow Transplantation,
pubmed-meshheading:15746436-CD40 Ligand,
pubmed-meshheading:15746436-Hypercholesterolemia,
pubmed-meshheading:15746436-Macrophages,
pubmed-meshheading:15746436-Mice,
pubmed-meshheading:15746436-Mice, Inbred C57BL,
pubmed-meshheading:15746436-Mice, Mutant Strains,
pubmed-meshheading:15746436-Muscle, Smooth, Vascular,
pubmed-meshheading:15746436-Receptors, LDL
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pubmed:year |
2005
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pubmed:articleTitle |
Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells.
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pubmed:affiliation |
Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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