Source:http://linkedlifedata.com/resource/pubmed/id/15717295
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-3-24
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| pubmed:abstractText |
Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of attention deficit hyperactivity disorder (ADHD). Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. We examined four polymorphisms in the MAO-A gene (30 bp promoter VNTR, CA microsatellite in intron 2, 941G/T SNP in exon 8, and A/G SNP in intron 12) as well as two markers in the MAO-B gene (CA microsatellite in intron 2 and T/C SNP in intron 13) for association with ADHD in an Irish sample of 179 nuclear families. TDT analysis of the examined MAO-A markers revealed a significant association of the more active MAO-A 941G allele with the disorder (chi2 = 5.1, P = 0.03, OR = 1.7). In addition, haplotype analysis revealed a significantly increased transmission of a haplotype consisting of the shorter allele of the promoter VNTR (allele 1), the 6-repeat allele of the CA microsatellite and the G-allele of the 941G/T SNP (famhap global statistic 34.54, P = 0.01) to ADHD cases. No significant distortion in the number of transmitted alleles was observed between the two examined MAO-B polymorphisms and ADHD. These findings suggest the importance of the 941G/T MAO-A polymorphism in the development of ADHD at least in the Irish population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1552-4841
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| pubmed:author |
pubmed-author:BeckerTimT,
pubmed-author:ConroyJudithJ,
pubmed-author:DomschkeKatharinaK,
pubmed-author:FitzgeraldMichaelM,
pubmed-author:FreitagChristineC,
pubmed-author:GillMichaelM,
pubmed-author:HawiZiarihZ,
pubmed-author:KirleyAiveenA,
pubmed-author:LoweNaomiN,
pubmed-author:MullinsCelineC,
pubmed-author:O'sullivanRoderickR,
pubmed-author:SheehanKarenK
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| pubmed:copyrightInfo |
Copyright 2005 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
5
|
| pubmed:volume |
134B
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
110-4
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| pubmed:dateRevised |
2008-5-21
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| pubmed:meshHeading |
pubmed-meshheading:15717295-Adult,
pubmed-meshheading:15717295-Alleles,
pubmed-meshheading:15717295-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:15717295-Child,
pubmed-meshheading:15717295-Dinucleotide Repeats,
pubmed-meshheading:15717295-Female,
pubmed-meshheading:15717295-Genotype,
pubmed-meshheading:15717295-Haplotypes,
pubmed-meshheading:15717295-Humans,
pubmed-meshheading:15717295-Ireland,
pubmed-meshheading:15717295-Linkage Disequilibrium,
pubmed-meshheading:15717295-Male,
pubmed-meshheading:15717295-Minisatellite Repeats,
pubmed-meshheading:15717295-Monoamine Oxidase,
pubmed-meshheading:15717295-Nuclear Family,
pubmed-meshheading:15717295-Review Literature as Topic
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children.
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| pubmed:affiliation |
Department of Genetics, Trinity College Dublin, Ireland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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