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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1992-5-28
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pubmed:abstractText |
Recombinant Interleukin-1 alpha (IL-1 alpha), Interleukin-2 (IL-2) and recombinant macrophage colony-stimulating factor-1 (M-CSF-1) as well as combinations of IL-2 and M-CSF-1 were studied for their ability to protect seven-day-old C57BL/6 mice against HSV-1 infection. Treatment of the mice with IL-2, M-CSF-1 or combinations of IL-2 and M-CSF-1 significantly increased survival rates. Treatment with IL-1 alpha (10 U and 100 U/mouse) was most effective in protection against HSV-1, resulting in significantly increased survival rates more than four times greater than the survival rate of the infected control group.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0304-8608
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1571022-Animals,
pubmed-meshheading:1571022-Animals, Newborn,
pubmed-meshheading:1571022-Brain,
pubmed-meshheading:1571022-Disease Models, Animal,
pubmed-meshheading:1571022-Herpes Simplex,
pubmed-meshheading:1571022-Injections, Intraperitoneal,
pubmed-meshheading:1571022-Interleukin-1,
pubmed-meshheading:1571022-Interleukin-2,
pubmed-meshheading:1571022-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:1571022-Mice,
pubmed-meshheading:1571022-Mice, Inbred C57BL,
pubmed-meshheading:1571022-Recombinant Proteins,
pubmed-meshheading:1571022-Survival Analysis,
pubmed-meshheading:1571022-Survival Rate
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pubmed:year |
1992
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pubmed:articleTitle |
Recombinant interleukin-1 alpha, interleukin-2 and M-CSF-1 enhance the survival of newborn C57BL/6 mice inoculated intraperitoneally with a lethal dose of herpes simplex virus-1.
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pubmed:affiliation |
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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