rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-2-2
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pubmed:abstractText |
A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/PTK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PXN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Paxillin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Like Protein p130
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1471-0072
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15688067-Animals,
pubmed-meshheading:15688067-Cell Membrane,
pubmed-meshheading:15688067-Cell Movement,
pubmed-meshheading:15688067-Cytoskeletal Proteins,
pubmed-meshheading:15688067-Cytoskeleton,
pubmed-meshheading:15688067-Focal Adhesion Kinase 1,
pubmed-meshheading:15688067-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:15688067-Humans,
pubmed-meshheading:15688067-Intercellular Junctions,
pubmed-meshheading:15688067-Paxillin,
pubmed-meshheading:15688067-Phosphoproteins,
pubmed-meshheading:15688067-Phosphorylation,
pubmed-meshheading:15688067-Protein Structure, Tertiary,
pubmed-meshheading:15688067-Protein-Tyrosine Kinases,
pubmed-meshheading:15688067-Proteins,
pubmed-meshheading:15688067-Retinoblastoma-Like Protein p130
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pubmed:year |
2005
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pubmed:articleTitle |
Focal adhesion kinase: in command and control of cell motility.
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pubmed:affiliation |
The Scripps Research Institute, Department of Immunology, IMM21 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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