Source:http://linkedlifedata.com/resource/pubmed/id/15652769
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001511,
umls-concept:C0011616,
umls-concept:C0025543,
umls-concept:C0026809,
umls-concept:C0033268,
umls-concept:C0039194,
umls-concept:C0392756,
umls-concept:C0599956,
umls-concept:C1136246,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C1879547,
umls-concept:C2752151,
umls-concept:C2828366,
umls-concept:C2930155
|
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-1-17
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| pubmed:abstractText |
In the present paper, the effect of the aqueous extract from aerial parts of Artemisia vestita (AV-ext), a traditional Tibetan medicine, on ear contact sensitivity was examined. AV-ext significantly reduced the ear swelling when administered during the induction phase of picryl-chloride (PCl)-induced ear contact sensitivity in mice. The extract also showed a dose-dependent inhibition on lymphocyte proliferation and IL-2 production in Con A-activated spleen cells. The proliferation inhibition was confirmed in the mixed lymphocytes reaction. Furthermore, the adhesion of the isolated spleen cells from PCl-sensitized mice to type IV collagen was significantly decreased in a dose-dependent manner by AV-ext. Such decrease was also seen in AV-ext-treated Jurkat T cells and the T cells purified from above spleen cells. The purified spleen T cells from PCl-sensitized mice produced more matrix metalloproteinase-9 (MMP-9) than naive T cells, and AV-ext remarkably reduced MMP-9 production both in vivo and in vitro. These results suggest that AV-ext may alleviate contact sensitivity through blocking the activation of T lymphocytes and decreasing their localization to the inflammatory sites via down-regulating the potential of cell adhesion and metalloproteinase production.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1567-5769
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
407-15
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15652769-Animals,
pubmed-meshheading:15652769-Artemisia,
pubmed-meshheading:15652769-Cell Adhesion,
pubmed-meshheading:15652769-Cell Proliferation,
pubmed-meshheading:15652769-Dermatitis, Allergic Contact,
pubmed-meshheading:15652769-Disease Models, Animal,
pubmed-meshheading:15652769-Dose-Response Relationship, Drug,
pubmed-meshheading:15652769-Down-Regulation,
pubmed-meshheading:15652769-Female,
pubmed-meshheading:15652769-Humans,
pubmed-meshheading:15652769-Jurkat Cells,
pubmed-meshheading:15652769-Lymphocyte Activation,
pubmed-meshheading:15652769-Matrix Metalloproteinase 9,
pubmed-meshheading:15652769-Medicine, Tibetan Traditional,
pubmed-meshheading:15652769-Mice,
pubmed-meshheading:15652769-Mice, Inbred BALB C,
pubmed-meshheading:15652769-Picryl Chloride,
pubmed-meshheading:15652769-Plant Components, Aerial,
pubmed-meshheading:15652769-Plant Extracts,
pubmed-meshheading:15652769-Spleen,
pubmed-meshheading:15652769-T-Lymphocytes
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Aqueous extract from aerial parts of Artemisia vestita, a traditional Tibetan medicine, reduces contact sensitivity in mice by down-regulating the activation, adhesion and metalloproteinase production of T lymphocytes.
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| pubmed:affiliation |
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|