Source:http://linkedlifedata.com/resource/pubmed/id/15649304
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-1-14
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| pubmed:abstractText |
A PCR restriction fragment length polymorphism assay was used to analyse single-nucleotide polymorphisms in the tumour necrosis factor (TNF)-alpha and TNF-beta genes of 56 patients with chronic severe hepatitis B virus (HBV) infection, 71 patients who either had chronic mild HBV infection or who were asymptomatic carriers, and 90 healthy controls. The serum TNF-alpha concentrations in patients with chronic severe HBV infection were compared to those of 30 healthy controls by radioimmunoassay. The frequencies of the TNF1/2 genotype and the TNF2 allele were greater in patients with chronic severe HBV infection than in healthy controls (25% vs. 11.1%, p 0.015; 12.5% vs. 5.6%, p 0.036, respectively) and patients with chronic mild HBV infection and asymptomatic carriers (25% vs. 8.8%, p 0.011; 12.5% vs. 4.2%, p 0.015, respectively). Heterozygotes carrying the TNF2 allele had higher levels of serum TNF-alpha than homozygotes for the wild-type allele among all patients with chronic severe HBV infection (p <0.01). The genotype distribution and allele frequency of TNF-beta were similar for patients with chronic severe HBV infection and healthy controls, but the frequency of the TNF-beta*2/2 genotype in patients with chronic mild HBV infection and asymptomatic controls was lower than for healthy controls (9.9% vs. 22.4%, p 0.043) or patients with chronic severe HBV infection (9.9% vs. 26.8%, p 0.043), although this was not significant after correction for multiple testing. It was concluded that TNF-alpha gene polymorphisms may play an important role as a host factor in the progression of HBV infection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1198-743X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
11
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
52-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15649304-Adult,
pubmed-meshheading:15649304-Alleles,
pubmed-meshheading:15649304-Female,
pubmed-meshheading:15649304-Gene Frequency,
pubmed-meshheading:15649304-Genotype,
pubmed-meshheading:15649304-Hepatitis B, Chronic,
pubmed-meshheading:15649304-Hepatitis B virus,
pubmed-meshheading:15649304-Humans,
pubmed-meshheading:15649304-Lymphotoxin-alpha,
pubmed-meshheading:15649304-Male,
pubmed-meshheading:15649304-Middle Aged,
pubmed-meshheading:15649304-Polymerase Chain Reaction,
pubmed-meshheading:15649304-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15649304-Polymorphism, Single Nucleotide,
pubmed-meshheading:15649304-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection.
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| pubmed:affiliation |
Institute of Infectious Disease, Xiangya Hospital, Central South University, Changsha, China. xuxuwen95@hotmail.com
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| pubmed:publicationType |
Journal Article
|