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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-2-15
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pubmed:abstractText |
Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of one of several duplicated SSX genes (most notably SSX1 and SSX2) at chromosome Xp11. SYT/SSX1 translocations are seen in nearly three times as many synovial sarcomas as SYT/SSX2 translocations. Although the SYT/SSX2 fusion is usually associated with the monophasic disease pattern, the SYT/SSX1 fusion is present in tumors with biphasic or monophasic patterns. The SYT/SSX1 fusion gene is associated with more aggressive tumor growth and poor outcome. Despite advances in the therapy of local disease, distant metastasis remains the predominant cause of death. Accordingly, there is a need for alternate therapies, such as those recently developed against the receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and HER-2/neu.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2005 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
830-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15641030-Adolescent,
pubmed-meshheading:15641030-Adult,
pubmed-meshheading:15641030-Aged,
pubmed-meshheading:15641030-Child,
pubmed-meshheading:15641030-Female,
pubmed-meshheading:15641030-Gene Amplification,
pubmed-meshheading:15641030-Humans,
pubmed-meshheading:15641030-Immunohistochemistry,
pubmed-meshheading:15641030-In Situ Hybridization,
pubmed-meshheading:15641030-Male,
pubmed-meshheading:15641030-Middle Aged,
pubmed-meshheading:15641030-Oncogene Proteins, Fusion,
pubmed-meshheading:15641030-RNA, Messenger,
pubmed-meshheading:15641030-Receptor, Epidermal Growth Factor,
pubmed-meshheading:15641030-Receptor, erbB-2,
pubmed-meshheading:15641030-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:15641030-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15641030-Sarcoma, Synovial,
pubmed-meshheading:15641030-Soft Tissue Neoplasms
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pubmed:year |
2005
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pubmed:articleTitle |
Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma.
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pubmed:affiliation |
Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109-0602, USA. Thomasda@med.umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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