Linked Life Data

15638952

Source:http://linkedlifedata.com/resource/pubmed/id/15638952

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pubmed-article:15638952pubmed:abstractTextThe gene coding for the 5-HT transporter (5-HTT) is considered as a candidate gene for schizophrenia, because this transporter plays a key role in serotonin neurotransmission. Previous genetic studies focusing on this gene yielded conflicting results, presumably because of stratification biases linked to the case-control association study approach, and the potential genetic and phenotypic heterogeneity of schizophrenia. We investigated the 5-HTTLPR and 17-bp VNTR (variable number of tandem repeats) polymorphisms of this gene in 103 trios using the transmission disequilibrium test. No preferential transmission of either allele of the 17-bp VNTR was observed, but an excess of transmission of the L allele of the 5-HTTLPR polymorphism was detected (p = 0.03). As the haplotype analyses did not improve the strength of the association, our data provide convergent evidence for a significant role of the 5-HTTLPR promoter polymorphism of the 5-HTT gene in the vulnerability to schizophrenia.lld:pubmed
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pubmed-article:15638952pubmed:articleTitleFamily-based association study of the 5-HT transporter gene and schizophrenia.lld:pubmed
pubmed-article:15638952pubmed:affiliationService de Psychiatrie Adultes, Faculty of Medicine Bichat-Claude Bernard, Louis Mourier Hospital (AP-HP), Colombes Cedex, France. caroline.dubertret@lmr.ap-hop-paris.frlld:pubmed
pubmed-article:15638952pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15638952pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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