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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-2-15
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pubmed:abstractText |
The gene coding for the 5-HT transporter (5-HTT) is considered as a candidate gene for schizophrenia, because this transporter plays a key role in serotonin neurotransmission. Previous genetic studies focusing on this gene yielded conflicting results, presumably because of stratification biases linked to the case-control association study approach, and the potential genetic and phenotypic heterogeneity of schizophrenia. We investigated the 5-HTTLPR and 17-bp VNTR (variable number of tandem repeats) polymorphisms of this gene in 103 trios using the transmission disequilibrium test. No preferential transmission of either allele of the 17-bp VNTR was observed, but an excess of transmission of the L allele of the 5-HTTLPR polymorphism was detected (p = 0.03). As the haplotype analyses did not improve the strength of the association, our data provide convergent evidence for a significant role of the 5-HTTLPR promoter polymorphism of the 5-HTT gene in the vulnerability to schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1461-1457
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15638952-Adult,
pubmed-meshheading:15638952-Aged,
pubmed-meshheading:15638952-Female,
pubmed-meshheading:15638952-Genetic Predisposition to Disease,
pubmed-meshheading:15638952-Genetic Variation,
pubmed-meshheading:15638952-Genotype,
pubmed-meshheading:15638952-Haplotypes,
pubmed-meshheading:15638952-Heterozygote Detection,
pubmed-meshheading:15638952-Humans,
pubmed-meshheading:15638952-Linkage Disequilibrium,
pubmed-meshheading:15638952-Male,
pubmed-meshheading:15638952-Membrane Glycoproteins,
pubmed-meshheading:15638952-Membrane Transport Proteins,
pubmed-meshheading:15638952-Middle Aged,
pubmed-meshheading:15638952-Nerve Tissue Proteins,
pubmed-meshheading:15638952-Phenotype,
pubmed-meshheading:15638952-Polymorphism, Genetic,
pubmed-meshheading:15638952-Promoter Regions, Genetic,
pubmed-meshheading:15638952-Schizophrenia,
pubmed-meshheading:15638952-Serotonin,
pubmed-meshheading:15638952-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:15638952-Synaptic Transmission
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pubmed:year |
2005
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pubmed:articleTitle |
Family-based association study of the 5-HT transporter gene and schizophrenia.
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pubmed:affiliation |
Service de Psychiatrie Adultes, Faculty of Medicine Bichat-Claude Bernard, Louis Mourier Hospital (AP-HP), Colombes Cedex, France. caroline.dubertret@lmr.ap-hop-paris.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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