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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-1-10
pubmed:abstractText
The role of endothelin-1 (ET-1) and of its receptor A (ETA) blockade in oedematous acute pancreatitis (AP) remains unclear. In 40 male Wistar rats with i.p. cerulein-induced AP, lasting 4 hours, ET-1 2x0.5 nmol/kg and 2x1.0 nmol/kg or selective ETA antagonist LU 302146, 10 mg/kg and 20 mg/kg was given i.p. simultaneously with cerulein. Histological and ultrastructural studies of pancreatic specimens were done. ET-1 decreased the inflammatory infiltration, but not the mean scores of necrosis and vacuolization in AP. The ultrastructural damage of acinar cells was less evident after ET-1 than in untreated AP. Selective ETA antagonist slightly aggravated the vacuolization and necrosis of acinar cells and some ultrastructural alterations in AP. In conclusion, ET-1, in contrast to selective ETA antagonist, exerts some protective effect in the early course of oedematous cerulein-induced acute pancreatitis in rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
49 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-9
pubmed:dateRevised
2006-1-6
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effects of endothelin-1 or of its receptor A a selective antagonist, on histological and ultrastructural patterns in experimental acute pancreatitis in rats.
pubmed:affiliation
Department of Medical Pathomorphology, Medical University of Bialystok, Poland. anna.andrzejewska@poczta.fm
pubmed:publicationType
Journal Article