Source:http://linkedlifedata.com/resource/pubmed/id/15638439
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2005-1-10
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pubmed:abstractText |
The role of endothelin-1 (ET-1) and of its receptor A (ETA) blockade in oedematous acute pancreatitis (AP) remains unclear. In 40 male Wistar rats with i.p. cerulein-induced AP, lasting 4 hours, ET-1 2x0.5 nmol/kg and 2x1.0 nmol/kg or selective ETA antagonist LU 302146, 10 mg/kg and 20 mg/kg was given i.p. simultaneously with cerulein. Histological and ultrastructural studies of pancreatic specimens were done. ET-1 decreased the inflammatory infiltration, but not the mean scores of necrosis and vacuolization in AP. The ultrastructural damage of acinar cells was less evident after ET-1 than in untreated AP. Selective ETA antagonist slightly aggravated the vacuolization and necrosis of acinar cells and some ultrastructural alterations in AP. In conclusion, ET-1, in contrast to selective ETA antagonist, exerts some protective effect in the early course of oedematous cerulein-induced acute pancreatitis in rats.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:author | |
pubmed:volume |
49 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-9
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pubmed:dateRevised |
2006-1-6
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pubmed:meshHeading |
pubmed-meshheading:15638439-Acute Disease,
pubmed-meshheading:15638439-Animals,
pubmed-meshheading:15638439-Cytoplasmic Granules,
pubmed-meshheading:15638439-Endothelin-1,
pubmed-meshheading:15638439-Male,
pubmed-meshheading:15638439-Pancreas,
pubmed-meshheading:15638439-Pancreatitis,
pubmed-meshheading:15638439-Rats,
pubmed-meshheading:15638439-Rats, Wistar,
pubmed-meshheading:15638439-Receptor, Endothelin A,
pubmed-meshheading:15638439-Vacuoles
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pubmed:year |
2004
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pubmed:articleTitle |
Effects of endothelin-1 or of its receptor A a selective antagonist, on histological and ultrastructural patterns in experimental acute pancreatitis in rats.
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pubmed:affiliation |
Department of Medical Pathomorphology, Medical University of Bialystok, Poland. anna.andrzejewska@poczta.fm
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pubmed:publicationType |
Journal Article
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