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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-12-31
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pubmed:abstractText |
Oral immunization of both humans and animals with non-replicating soluble antigens often results in the induction of oral tolerance. However, receptor-dependent uptake of orally administered soluble antigens can lead to the induction of an antigen-specific immune response. Indeed, oral immunization of pigs with recombinant FaeG (rFaeG), the adhesin of the F4(K88) fimbriae of enterotoxigenic Escherichia coli (ETEC), induces an F4-specific humoral and cellular immune response. This response is accompanied with a reduction in the excretion of F4(+)E. coli following challenge. To improve the immune response against F4, rFaeG was orally co-administered with the mucosal adjuvant cholera toxin (CT). Oral immunization of pigs with rFaeG and CT significantly improved the induction of an F4-specific humoral and cellular immune response and also significantly reduced the faecal F4(+)E. coli excretion following F4(+) ETEC challenge as compared to rFaeG-immunized pigs. Therefore, the present study demonstrates that CT can act in pigs as a mucosal adjuvant for antigens that bind to the intestinal epithelium by a CT-receptor-independent mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adhesins, Escherichia coli,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Cholera Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/FaeG protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/Fimbriae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/K88 antigen, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-2427
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-9
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pubmed:meshHeading |
pubmed-meshheading:15626459-Adhesins, Escherichia coli,
pubmed-meshheading:15626459-Administration, Oral,
pubmed-meshheading:15626459-Animals,
pubmed-meshheading:15626459-Antibodies, Bacterial,
pubmed-meshheading:15626459-Antigens, Bacterial,
pubmed-meshheading:15626459-Cholera Toxin,
pubmed-meshheading:15626459-Escherichia coli Proteins,
pubmed-meshheading:15626459-Escherichia coli Vaccines,
pubmed-meshheading:15626459-Fimbriae Proteins,
pubmed-meshheading:15626459-Immunization,
pubmed-meshheading:15626459-Recombinant Proteins,
pubmed-meshheading:15626459-Swine,
pubmed-meshheading:15626459-Vaccines, Synthetic
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pubmed:year |
2005
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pubmed:articleTitle |
Cholera toxin improves the F4(K88)-specific immune response following oral immunization of pigs with recombinant FaeG.
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pubmed:affiliation |
Laboratory of Veterinary Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. frank.verdonch@ugent.ac.be
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pubmed:publicationType |
Journal Article
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