|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-2-16
|
|
pubmed:abstractText |
Constitutive models are needed to relate the active and passive mechanical properties of cells to the overall mechanical response of bio-artificial tissues. The Zahalak model attempts to explicitly describe this link for a class of bio-artificial tissues. A fundamental assumption made by Zahalak is that cells stretch in perfect registry with a tissue. We show this assumption to be valid only for special cases, and we correct the Zahalak model accordingly. We focus on short-term and very long-term behavior, and therefore consider tissue constituents that are linear in their loading response (although not necessarily linear in unloading). In such cases, the average strain in a cell is related to the macroscopic tissue strain by a scalar we call the "strain factor". We incorporate a model predicting the strain factor into the Zahalak model, and then reinterpret experiments reported by Zahalak and co-workers to determine the in situ stiffness of cells in a tissue construct. We find that, without the modification in this article, the Zahalak model can underpredict cell stiffness by an order of magnitude.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-10332619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-10367015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-10733956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-10784096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-10923292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-10991422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-11006391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-11053116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-11580676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-12002131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-14649502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-3282560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-6957866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-8666595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-8748520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-9245747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-9746546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15596492-9876170
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0006-3495
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
88
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
765-77
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:15596492-Animals,
pubmed-meshheading:15596492-Bioartificial Organs,
pubmed-meshheading:15596492-Cell Physiological Phenomena,
pubmed-meshheading:15596492-Cells, Cultured,
pubmed-meshheading:15596492-Computer Simulation,
pubmed-meshheading:15596492-Elasticity,
pubmed-meshheading:15596492-Extracellular Matrix,
pubmed-meshheading:15596492-Humans,
pubmed-meshheading:15596492-Mechanotransduction, Cellular,
pubmed-meshheading:15596492-Membranes, Artificial,
pubmed-meshheading:15596492-Models, Biological,
pubmed-meshheading:15596492-Stress, Mechanical,
pubmed-meshheading:15596492-Tensile Strength,
pubmed-meshheading:15596492-Tissue Engineering
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Thin bio-artificial tissues in plane stress: the relationship between cell and tissue strain, and an improved constitutive model.
|
|
pubmed:affiliation |
Department of Mechanical Engineering, Washington University, St. Louis, Missouri 63130, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Evaluation Studies,
Research Support, N.I.H., Extramural,
Validation Studies
|
