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rdf:type |
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lifeskim:mentions |
umls-concept:C0003693,
umls-concept:C0013725,
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0040690,
umls-concept:C0185117,
umls-concept:C0205821,
umls-concept:C0220781,
umls-concept:C0225369,
umls-concept:C0851285,
umls-concept:C1883254,
umls-concept:C2911684,
umls-concept:C2936832
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-15
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pubmed:abstractText |
To explore the modulation of 5-lipoxygenase-activating protein (FLAP) and 5-lipoxygenase (5-LOX) expression in human osteoarthritic (OA) chondrocytes, their relative implications in leukotriene B(4) (LTB(4)) production, the effect of different factors on this system, and the influence of increased LTB(4) production on the synthesis of catabolic factors of cartilage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-Lipoxygenase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ALOX5AP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 5-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3925-33
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15593193-5-Lipoxygenase-Activating Proteins,
pubmed-meshheading:15593193-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:15593193-Calcitriol,
pubmed-meshheading:15593193-Carrier Proteins,
pubmed-meshheading:15593193-Cartilage, Articular,
pubmed-meshheading:15593193-Cells, Cultured,
pubmed-meshheading:15593193-Chondrocytes,
pubmed-meshheading:15593193-Cyclooxygenase Inhibitors,
pubmed-meshheading:15593193-Dinoprostone,
pubmed-meshheading:15593193-Drug Combinations,
pubmed-meshheading:15593193-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15593193-Gene Expression Regulation,
pubmed-meshheading:15593193-Humans,
pubmed-meshheading:15593193-Leukotriene B4,
pubmed-meshheading:15593193-Matrix Metalloproteinase 1,
pubmed-meshheading:15593193-Membrane Proteins,
pubmed-meshheading:15593193-Middle Aged,
pubmed-meshheading:15593193-Nitric Oxide,
pubmed-meshheading:15593193-Osteoarthritis, Knee,
pubmed-meshheading:15593193-RNA, Messenger,
pubmed-meshheading:15593193-Transforming Growth Factor beta,
pubmed-meshheading:15593193-Transforming Growth Factor beta1,
pubmed-meshheading:15593193-Up-Regulation
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pubmed:year |
2004
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pubmed:articleTitle |
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
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pubmed:affiliation |
Osteoarthritis Research Unit, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montreal, Quebec, Canada. jm@martelpelletier.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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