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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0037083,
umls-concept:C0040690,
umls-concept:C0292688,
umls-concept:C0871261,
umls-concept:C1123023,
umls-concept:C1533157,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1710082,
umls-concept:C2911692
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-15
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pubmed:abstractText |
Members of the transforming growth factor beta (TGFbeta) cytokine superfamily play critical roles in both homeostasis and disease. In light of their profibrotic effects, these molecules are implicated in the pathogenesis of fibrosis. In fibroblasts, TGFbeta signals through the activin receptor-like kinase 5 (ALK-5) type I TGFbeta and triggers Smad and MAP kinase signaling pathways. Because targeting of TGFbeta signaling represents a potential approach to the treatment of systemic sclerosis (SSc) and other fibrotic disorders, we investigated the modulation of intracellular TGFbeta signal transduction by SB431542, the first small-molecule inhibitor of ALK-5 to be described.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(5-benzo(1,3)dioxol-5-yl-4-pyridin...,
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxoles,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4008-21
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15593186-Activin Receptors, Type I,
pubmed-meshheading:15593186-Adult,
pubmed-meshheading:15593186-Benzamides,
pubmed-meshheading:15593186-Cells, Cultured,
pubmed-meshheading:15593186-DNA-Binding Proteins,
pubmed-meshheading:15593186-Dioxoles,
pubmed-meshheading:15593186-Enzyme Inhibitors,
pubmed-meshheading:15593186-Female,
pubmed-meshheading:15593186-Fibroblasts,
pubmed-meshheading:15593186-Fibrosis,
pubmed-meshheading:15593186-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:15593186-Gene Expression,
pubmed-meshheading:15593186-Humans,
pubmed-meshheading:15593186-In Situ Hybridization,
pubmed-meshheading:15593186-Infant, Newborn,
pubmed-meshheading:15593186-Male,
pubmed-meshheading:15593186-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15593186-RNA, Messenger,
pubmed-meshheading:15593186-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:15593186-Signal Transduction,
pubmed-meshheading:15593186-Skin,
pubmed-meshheading:15593186-Smad Proteins,
pubmed-meshheading:15593186-Trans-Activators,
pubmed-meshheading:15593186-Transforming Growth Factor beta
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pubmed:year |
2004
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pubmed:articleTitle |
Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.
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pubmed:affiliation |
University of Illinois College of Medicine, Chicago.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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