Source:http://linkedlifedata.com/resource/umls/id/C0292688
NCI: Expressed in all tissues (most in placenta) by human TGFBR1 Gene (TGFBR Ser/Thr Family), 503-aa 53-kDa (56-kDa precursor) Transforming Growth Factor Beta Receptor I is a type I transmembrane protein receptor for multifunctional cytokine TGFB1 containing a signal peptide, an extracellular Cys-rich region with an N-glycosylation site, a transmembrane region, and a cytoplasmic protein Ser/Thr kinase domain that mediates induction of cell-matrix adhesion genes and regulates cell cycle progression. TGF-beta binds either TGFBR1 or transmembrane Ser/Thr TGF-Beta II receptor, which form an active heterodimeric complex. TGFB stimulation leads to phosphorylation and activation of SMAD2 and SMAD3, which, complexed with SMAD4, accumulate in the nucleus and regulate transcription of target genes. Continuous SMAD nucleocytoplasmic shuttling during TGFB signaling monitors receptor activity. (NCI)