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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-12-13
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|
pubmed:abstractText |
Circulating monocytic cells may mediate neuroinvasion in transmissible spongiform encephalopathies by transporting prion protein (PrP) from sites of entry to the nervous system. Factors regulating monocyte-derived dendritic cell (DC) functions in neuronal tissue include neurogenic mediators, but their interactions with prion-infected DCs are unknown. Here, we report that neuropeptides regulate the interaction of DCs exposed to PrP(106-126). Inhibition of neurokinin-1-receptors activation with neurokinin-1-receptor antagonist or antibody attenuates substance P-induced enhancement of DC migration induced by PrP(106-126) and prion-protein-induced DC maturation. Other neuropeptides arrest chemotaxis. Data support a priming role of the neuropeptide substance P in PrP(106-126)-induced migration of DCs involving neurokinin-1-receptors.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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|
pubmed:issn |
0165-5728
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
153-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15589049-Antibodies,
pubmed-meshheading:15589049-Antigens, CD80,
pubmed-meshheading:15589049-Cell Aging,
pubmed-meshheading:15589049-Cell Movement,
pubmed-meshheading:15589049-Cells, Cultured,
pubmed-meshheading:15589049-Chemotaxis,
pubmed-meshheading:15589049-Dendritic Cells,
pubmed-meshheading:15589049-Dose-Response Relationship, Drug,
pubmed-meshheading:15589049-Drug Interactions,
pubmed-meshheading:15589049-Flow Cytometry,
pubmed-meshheading:15589049-HLA-DR Antigens,
pubmed-meshheading:15589049-Humans,
pubmed-meshheading:15589049-Neuropeptides,
pubmed-meshheading:15589049-Peptide Fragments,
pubmed-meshheading:15589049-Prions,
pubmed-meshheading:15589049-Receptors, Neurokinin-1,
pubmed-meshheading:15589049-Statistics, Nonparametric
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Neurokinin-1 receptor interacts with PrP(106-126)-induced dendritic cell migration and maturation.
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|
pubmed:affiliation |
Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study
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