Linked Life Data

15582654

Source:http://linkedlifedata.com/resource/pubmed/id/15582654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-7
pubmed:abstractText
Many paramyxoviruses appear to require cytoskeletal elements for particular steps in the virus life cycle. Measles virus and Sendai virus exhibit a requirement for microtubules in replication in vitro, whereas parainfluenza virus type 3 and RSV require actin for replication. To further elucidate the role of cytoskeletal function and rearrangement in the viral life cycle of RSV, we investigated the efficiency of virus entry, transcription, replication, and budding in the presence of a variety of pharmacological agents that stabilize or depolymerize actin or microtubules. We found that alteration of microtubule or actin function resulted in blocks at entry, formation of cell-associated virus, virus release, local cell-to-cell spread, and syncytium formation. Actin and microtubules act in cooperation to facilitate replication of RSV, although microtubules play a dominant role in the formation of cell-associated virus while actin plays a more prominent role in virus release.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
331
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus.
pubmed:affiliation
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.