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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-12-3
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pubmed:abstractText |
IL-1 receptor antagonist-deficient (IL-1Ra(-/-)) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell-deficient IL-1Ra(-/-) mice did not develop arthritis, and transfer of IL-1Ra(-/-) T cells induced arthritis in nu/nu mice. Development of arthritis was also markedly suppressed by TNF-alpha deficiency. We found that TNF-alpha induced OX40 expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis. These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10204494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10366125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10450517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10528210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10637275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10647992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-10835684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11086043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11244034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11342576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11407688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11418636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11441109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11899425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-11929124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-12093872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-12220548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-12354389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-12721360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-14634133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-1502148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-7560066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-8406562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-8717520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-9547794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-9565638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15578092-9597123
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Il1rn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:AbeRyoR,
pubmed-author:HabiroKatsuyoshiK,
pubmed-author:HoraiReikoR,
pubmed-author:IkuseToshimiT,
pubmed-author:IshiiNaotoN,
pubmed-author:IwakuraYoichiroY,
pubmed-author:KotakiHayatoH,
pubmed-author:KotaniMotokoM,
pubmed-author:MatsukiTaizoT,
pubmed-author:NakaeSusumuS,
pubmed-author:NakajimaAkikoA,
pubmed-author:NambuAyaA,
pubmed-author:OkaharaAkihikoA,
pubmed-author:SaijoShinobuS,
pubmed-author:SchwartzbergPamela LPL,
pubmed-author:SudoKatsukoK,
pubmed-author:TaniokaHidetoshiH
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1603-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15578092-Animals,
pubmed-meshheading:15578092-Antigens, CD40,
pubmed-meshheading:15578092-Antirheumatic Agents,
pubmed-meshheading:15578092-Arthritis, Experimental,
pubmed-meshheading:15578092-Arthritis, Rheumatoid,
pubmed-meshheading:15578092-Cell Transplantation,
pubmed-meshheading:15578092-Cytokines,
pubmed-meshheading:15578092-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:15578092-Joints,
pubmed-meshheading:15578092-Lymphocyte Activation,
pubmed-meshheading:15578092-Mice,
pubmed-meshheading:15578092-Mice, Inbred BALB C,
pubmed-meshheading:15578092-Mice, Inbred C57BL,
pubmed-meshheading:15578092-Mice, Knockout,
pubmed-meshheading:15578092-Mice, Nude,
pubmed-meshheading:15578092-Mice, SCID,
pubmed-meshheading:15578092-Receptors, Interleukin-1,
pubmed-meshheading:15578092-Receptors, OX40,
pubmed-meshheading:15578092-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:15578092-Sialoglycoproteins,
pubmed-meshheading:15578092-T-Lymphocytes,
pubmed-meshheading:15578092-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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