Linked Life Data

15578048

Source:http://linkedlifedata.com/resource/pubmed/id/15578048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-2-17
pubmed:abstractText
It has been suggested that increased oxidative stress may be both a cause as well as a consequence of hypertension. In vivo oxidation of low-density lipoproteins by oxygen-free radicals may increase hypertension-related atherogenesis, and antioxidants may be beneficial in this regard. Previous findings concerning associations between serum measures of antioxidants and hypertension have however been inconsistent. Plasma levels of beta-carotene, Vitamin A, E, uric acid, homocysteine and total antioxidant capacity, as well as two markers of oxidative stress, malondialdehyde (MDA) and protein carbonyls, were measured in morning fasting blood samples provided by 415 Australians aged 60-64 years, selected randomly from the community. Participants also provided information on sociodemographic attributes, mental and physical health, and provided two measures of resting blood pressure, allowing a diagnosis of definite or borderline hypertension. Those with hypertension had lower levels of beta-carotene and higher levels of uric acid and MDA compared to normotensive participants. The last two of these associations persisted when the analyses controlled for lifestyle and health factors. The findings from this study offer limited support for the proposition that lower antioxidant status and higher oxidative stress are associated with hypertension, and suggest the need for longitudinal studies to examine causality and intervention studies to determine the benefit of antioxidants in this group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0950-9240
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15578048-Age Factors, pubmed-meshheading:15578048-Antioxidants, pubmed-meshheading:15578048-Biological Markers, pubmed-meshheading:15578048-Blood Pressure, pubmed-meshheading:15578048-Chromatography, High Pressure Liquid, pubmed-meshheading:15578048-Cross-Over Studies, pubmed-meshheading:15578048-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:15578048-Female, pubmed-meshheading:15578048-Homocysteine, pubmed-meshheading:15578048-Humans, pubmed-meshheading:15578048-Hypertension, pubmed-meshheading:15578048-Life Style, pubmed-meshheading:15578048-Longitudinal Studies, pubmed-meshheading:15578048-Male, pubmed-meshheading:15578048-Malondialdehyde, pubmed-meshheading:15578048-Middle Aged, pubmed-meshheading:15578048-New South Wales, pubmed-meshheading:15578048-Oxidative Stress, pubmed-meshheading:15578048-Residence Characteristics, pubmed-meshheading:15578048-Retrospective Studies, pubmed-meshheading:15578048-Risk Factors, pubmed-meshheading:15578048-Urban Population, pubmed-meshheading:15578048-Uric Acid, pubmed-meshheading:15578048-Vitamin A, pubmed-meshheading:15578048-Vitamin E, pubmed-meshheading:15578048-beta Carotene
pubmed:year
2005
pubmed:articleTitle
Associations between plasma antioxidants and hypertension in a community-based sample of 415 Australians aged 60-64.
pubmed:affiliation
Centre for Mental Health Research, Australian National University, Canberra, Australia. ruth.parslow@anu.edu.au
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial