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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2004-11-15
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pubmed:abstractText |
BRAF mutations are common in sporadic colorectal cancers (CRCs) with a DNA mismatch repair (MMR) deficiency that results from promoter methylation of hMLH1, whereas KRAS mutations are common in MMR proficient CRCs associated with promoter methylation of MGMT. The aim of this study was to further investigate the link between genetic alterations in the RAS/RAF/ERK pathway and an underlying epigenetic disorder.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:CullingsHarry MHM,
pubmed-author:JassJeremy RJR,
pubmed-author:KambaraTakeshiT,
pubmed-author:KimuraKeigoK,
pubmed-author:LeggettBarbara ABA,
pubmed-author:MacPheeDonald GDG,
pubmed-author:MatsubaraNagahideN,
pubmed-author:NagasakaTakeshiT,
pubmed-author:NotoharaKenjiK,
pubmed-author:SasamotoHiromiH,
pubmed-author:TakedaMasanoriM,
pubmed-author:TanakaNoriakiN,
pubmed-author:YoungJoanneJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4584-94
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15542810-Aged,
pubmed-meshheading:15542810-Case-Control Studies,
pubmed-meshheading:15542810-Colorectal Neoplasms,
pubmed-meshheading:15542810-DNA Methylation,
pubmed-meshheading:15542810-DNA Mutational Analysis,
pubmed-meshheading:15542810-DNA Repair,
pubmed-meshheading:15542810-Female,
pubmed-meshheading:15542810-Genes, ras,
pubmed-meshheading:15542810-Humans,
pubmed-meshheading:15542810-Immunohistochemistry,
pubmed-meshheading:15542810-Male,
pubmed-meshheading:15542810-Middle Aged,
pubmed-meshheading:15542810-Polymerase Chain Reaction,
pubmed-meshheading:15542810-Promoter Regions, Genetic,
pubmed-meshheading:15542810-Proto-Oncogene Proteins B-raf
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pubmed:year |
2004
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pubmed:articleTitle |
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.
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pubmed:affiliation |
Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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