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rdf:type |
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lifeskim:mentions |
umls-concept:C0020202,
umls-concept:C0020205,
umls-concept:C0023175,
umls-concept:C0023688,
umls-concept:C0066677,
umls-concept:C0205250,
umls-concept:C0243077,
umls-concept:C0596902,
umls-concept:C0599682,
umls-concept:C0920472,
umls-concept:C1144251
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pubmed:issue |
24
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pubmed:dateCreated |
2004-11-11
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pubmed:abstractText |
Some piperidine-based nocaine/modafinil hybrid ligands have been designed, synthesized, and found to display an improved potency at all three monoamine transporters and particularly for DAT and/or NET. Some highly active and selective monoamine transporter inhibitors with low nanomolar to subnanomolar potency were identified. Ligands of this type may find important applications as positron emission tomography imaging tools and in the treatment of central nervous system disorders such as depression and sleep apnea.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-10425082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-10481909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-10560029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-11222668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-11382857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-11691979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-11803442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-12109901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-12235253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-12377578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-12403988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-12649362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-1973114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-7991954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-8813612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15537337-9599245
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzhydryl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/methyl...,
http://linkedlifedata.com/resource/pubmed/chemical/modafinil
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5821-4
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pubmed:dateRevised |
2011-3-17
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pubmed:meshHeading |
pubmed-meshheading:15537337-Animals,
pubmed-meshheading:15537337-Benzhydryl Compounds,
pubmed-meshheading:15537337-Biological Availability,
pubmed-meshheading:15537337-Cocaine,
pubmed-meshheading:15537337-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:15537337-Drug Design,
pubmed-meshheading:15537337-Ligands,
pubmed-meshheading:15537337-Membrane Glycoproteins,
pubmed-meshheading:15537337-Membrane Transport Modulators,
pubmed-meshheading:15537337-Membrane Transport Proteins,
pubmed-meshheading:15537337-Motor Activity,
pubmed-meshheading:15537337-Nerve Endings,
pubmed-meshheading:15537337-Nerve Tissue Proteins,
pubmed-meshheading:15537337-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:15537337-Piperidines,
pubmed-meshheading:15537337-Rats,
pubmed-meshheading:15537337-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:15537337-Symporters,
pubmed-meshheading:15537337-Synaptosomes
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pubmed:year |
2004
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pubmed:articleTitle |
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.
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pubmed:affiliation |
Acenta Discovery, Inc., 9030 S. Rita Road, Suite 300, Tucson, Arizona 85747-9101, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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