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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0035412,
umls-concept:C0039593,
umls-concept:C0067053,
umls-concept:C0185117,
umls-concept:C0370003,
umls-concept:C0449560,
umls-concept:C0936012,
umls-concept:C1440080,
umls-concept:C1521991,
umls-concept:C1522609,
umls-concept:C1554112,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-13
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pubmed:abstractText |
Identification of the alveolar subtype of rhabdomyosarcoma (ARMS) is important, because the poor prognosis associated with this subtype necessitates a modified therapeutic regimen. At present, ARMS diagnoses are made on the basis of histologic findings and the extent of myogenin immunopositivity. Nonetheless, the absence of an alveolar pattern in the solid variant, the low degree of differentiation in certain embryonal rhabdomyosarcomas (ERMS), and the increasing use of microbiopsy samples make the diagnosis of ARMS somewhat difficult. Two specific translocations have been found in ARMS, and fusion transcripts can be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of paraffin-embedded tissue (PET).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FOXO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/MYOG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myogenin,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/PAX3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PAX3-FOXO1A fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:Andraud-FregevilleMarieM,
pubmed-author:BuiNguyen BinhNB,
pubmed-author:CoindreJean-MichelJM,
pubmed-author:DelattreOlivierO,
pubmed-author:DeminièreColetteC,
pubmed-author:GuillouLouisL,
pubmed-author:HosteinIsabelleI,
pubmed-author:LongavenneElisabethE,
pubmed-author:LussanCatherineC,
pubmed-author:RanchèreDominiqueD,
pubmed-author:Terrier-LacombeMarie-JoséMJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2817-24
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pubmed:dateRevised |
2008-5-6
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pubmed:meshHeading |
pubmed-meshheading:15536621-Adolescent,
pubmed-meshheading:15536621-Adult,
pubmed-meshheading:15536621-Aged,
pubmed-meshheading:15536621-Child,
pubmed-meshheading:15536621-Child, Preschool,
pubmed-meshheading:15536621-DNA-Binding Proteins,
pubmed-meshheading:15536621-Forkhead Transcription Factors,
pubmed-meshheading:15536621-Frozen Sections,
pubmed-meshheading:15536621-Humans,
pubmed-meshheading:15536621-Infant,
pubmed-meshheading:15536621-Infant, Newborn,
pubmed-meshheading:15536621-Middle Aged,
pubmed-meshheading:15536621-Myogenin,
pubmed-meshheading:15536621-Oncogene Proteins, Fusion,
pubmed-meshheading:15536621-Paired Box Transcription Factors,
pubmed-meshheading:15536621-Paraffin Embedding,
pubmed-meshheading:15536621-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15536621-Rhabdomyosarcoma, Alveolar,
pubmed-meshheading:15536621-Rhabdomyosarcoma, Embryonal,
pubmed-meshheading:15536621-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens.
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pubmed:affiliation |
Department of Pathology, Institut Bergonié, Bordeaux, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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