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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-11-9
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pubmed:abstractText |
To develop an efficient strategy for mapping genetic factors associated with common diseases, we constructed linkage disequilibrium (LD) maps of human chromosomes 5, 7, 17, and X. These maps consist of common single nucleotide polymorphisms at an average intermarker distance of 100 kb. The genotype data from these markers in a panel of American samples of European descent were analyzed to produce blocks of markers in strong pair-wise LD. Power calculations were used to guide block definitions and predicted that high-level LD maps would be useful in initial genome scans for susceptibility alleles in case-control association studies of complex diseases. As anticipated, LD blocks on the X chromosome were larger and covered more of the chromosome than those found on the autosomes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0888-7543
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pubmed:author |
pubmed-author:DonaldsonRR,
pubmed-author:DrendelAA,
pubmed-author:DuanSS,
pubmed-author:FlagstadLL,
pubmed-author:JORIHH,
pubmed-author:KlossE FEF,
pubmed-author:LinkMM,
pubmed-author:LovinsE GEG,
pubmed-author:MillerR DRD,
pubmed-author:MillerSS,
pubmed-author:POET HTH,
pubmed-author:PhongAA,
pubmed-author:RiceJ PJP,
pubmed-author:SacconeN LNL,
pubmed-author:SacconeS FSF,
pubmed-author:Taillon-MillerPP
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
899-912
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15533707-African Americans,
pubmed-meshheading:15533707-Algorithms,
pubmed-meshheading:15533707-Asian Continental Ancestry Group,
pubmed-meshheading:15533707-Case-Control Studies,
pubmed-meshheading:15533707-Chromosome Mapping,
pubmed-meshheading:15533707-Chromosomes, Human, Pair 13,
pubmed-meshheading:15533707-Chromosomes, Human, X,
pubmed-meshheading:15533707-European Continental Ancestry Group,
pubmed-meshheading:15533707-Gene Frequency,
pubmed-meshheading:15533707-Genetic Predisposition to Disease,
pubmed-meshheading:15533707-Genome, Human,
pubmed-meshheading:15533707-Genotype,
pubmed-meshheading:15533707-Humans,
pubmed-meshheading:15533707-Linkage Disequilibrium,
pubmed-meshheading:15533707-Polymorphism, Single Nucleotide
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pubmed:year |
2004
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pubmed:articleTitle |
Linkage disequilibrium maps constructed with common SNPs are useful for first-pass disease association screens.
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pubmed:affiliation |
Department of Dermatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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