| pubmed-article:15518173 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C0162969 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15518173 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15518173 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15518173 | pubmed:dateCreated | 2004-11-2 | lld:pubmed |
| pubmed-article:15518173 | pubmed:abstractText | Mast cells are known to play an active role as effector cells in allergic inflammation and in diverse immunological and pathological processes. Activated mast cell-derived pro-inflammatory cytokines are important pathologic factors of progression of allergic inflammation. In this study, we investigated whether pro-inflammatory cytokines (TNF-alpha and IL-8) can be induced by calcium stimulation in HMC-1 cells, and high molecular weight water-soluble chitosan (WSC) can inhibit the production of these cytokines. We provided evidence that the secretion of TNF-alpha and IL-8 from HMC-1 cells was induced by Ca2+-ionophore A23187 or Ca2+-ATPase inhibitor TSG. Treatment of WSC (10 microg/ml) prior to stimulation with calcium agonists significantly blocked the secretion of TNF-alpha by 65.1% for A23187 and 87.7% for TSG. IL-8 secretion in response to A23187 or TSG was inhibited by 49.2% for A23187 and 34.1% for TSG, respectively, compared to absence of WSC. These results suggest that WSC has potential regulatory effects on allergic inflammatory diseases by down-modulating Ca2+-induced mast cell activation. | lld:pubmed |
| pubmed-article:15518173 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15518173 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15518173 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15518173 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15518173 | pubmed:issn | 0892-3973 | lld:pubmed |
| pubmed-article:15518173 | pubmed:author | pubmed-author:KimHyung-MinH... | lld:pubmed |
| pubmed-article:15518173 | pubmed:author | pubmed-author:KimMi-SunMS | lld:pubmed |
| pubmed-article:15518173 | pubmed:author | pubmed-author:KimNam-SongNS | lld:pubmed |
| pubmed-article:15518173 | pubmed:author | pubmed-author:ShimBum... | lld:pubmed |
| pubmed-article:15518173 | pubmed:author | pubmed-author:YouHyun JaHJ | lld:pubmed |
| pubmed-article:15518173 | pubmed:author | pubmed-author:YouMi KyungMK | lld:pubmed |
| pubmed-article:15518173 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15518173 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:15518173 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15518173 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15518173 | pubmed:pagination | 401-9 | lld:pubmed |
| pubmed-article:15518173 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:meshHeading | pubmed-meshheading:15518173... | lld:pubmed |
| pubmed-article:15518173 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15518173 | pubmed:articleTitle | Inhibitory effect of water-soluble chitosan on TNF-alpha and IL-8 secretion from HMC-1 cells. | lld:pubmed |
| pubmed-article:15518173 | pubmed:affiliation | College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. | lld:pubmed |
| pubmed-article:15518173 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15518173 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15518173 | lld:pubmed |
