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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-10-29
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pubmed:abstractText |
Red blood cell (pRBC) transfusion is an independent risk factor for multiple organ failure (MOF); a maladaptive immuno-inflammatory response is implicated. Interleukin-8 (IL-8) is one putative mediator of this response. We previously observed that injured patients resuscitated with pRBCs have increased plasma IL-8 compared with those given human polymerized hemoglobin (PolyHb). To further elucidate the mechanisms responsible for this difference in IL-8, we devised an ex-vivo transfusion model. We hypothesize that pRBC transfusion induces increased IL-8 gene expression that is avoided by the use of PolyHb.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-5282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
720-4; discussion 724-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15514524-Analysis of Variance,
pubmed-meshheading:15514524-Blood Substitutes,
pubmed-meshheading:15514524-Cells, Cultured,
pubmed-meshheading:15514524-Erythrocyte Transfusion,
pubmed-meshheading:15514524-Gene Expression Regulation,
pubmed-meshheading:15514524-Graft Rejection,
pubmed-meshheading:15514524-Hemoglobins,
pubmed-meshheading:15514524-Humans,
pubmed-meshheading:15514524-Interleukin-8,
pubmed-meshheading:15514524-Leukocytes,
pubmed-meshheading:15514524-Multiple Organ Failure,
pubmed-meshheading:15514524-Neutrophils,
pubmed-meshheading:15514524-Probability,
pubmed-meshheading:15514524-RNA,
pubmed-meshheading:15514524-Risk Factors,
pubmed-meshheading:15514524-Sampling Studies,
pubmed-meshheading:15514524-Sensitivity and Specificity
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pubmed:year |
2004
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pubmed:articleTitle |
Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin.
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pubmed:affiliation |
Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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