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rdf:type |
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lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0017066,
umls-concept:C0023779,
umls-concept:C0033262,
umls-concept:C0205314,
umls-concept:C0286079,
umls-concept:C0439596,
umls-concept:C0444626,
umls-concept:C0679622,
umls-concept:C1522223,
umls-concept:C1880022
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-26
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pubmed:abstractText |
In an earlier study, a novel intraocular drug-delivery system was reported in which hexadecyloxypropyl-phospho-ganciclovir (HDP-P-GCV) was used as a prototype. The hypothesis was that many biologically effective compounds could be modified to crystalline lipid prodrugs and could be delivered directly into the vitreous in a long-lasting, slow-release form. This study was undertaken to characterize this new drug-delivery system further, by using small particles of HDP-P-GCV and hexadecyloxypropyl-cyclic cidofovir (HDP-cCDV).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-10359331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-10458299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-11227995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-11818399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-12121908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-12516724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-12606777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-12804061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-7840575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-7945041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-8670758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15505067-9262540
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4138-44
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pubmed:dateRevised |
2011-1-20
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pubmed:meshHeading |
pubmed-meshheading:15505067-Animals,
pubmed-meshheading:15505067-Antiviral Agents,
pubmed-meshheading:15505067-Area Under Curve,
pubmed-meshheading:15505067-Biological Availability,
pubmed-meshheading:15505067-Chromatography, High Pressure Liquid,
pubmed-meshheading:15505067-Cytosine,
pubmed-meshheading:15505067-Drug Delivery Systems,
pubmed-meshheading:15505067-Eye Infections, Viral,
pubmed-meshheading:15505067-Ganciclovir,
pubmed-meshheading:15505067-Herpes Simplex,
pubmed-meshheading:15505067-Herpesvirus 1, Human,
pubmed-meshheading:15505067-Liposomes,
pubmed-meshheading:15505067-Microfluidics,
pubmed-meshheading:15505067-Phosphonic Acids,
pubmed-meshheading:15505067-Prodrugs,
pubmed-meshheading:15505067-Rabbits,
pubmed-meshheading:15505067-Retina,
pubmed-meshheading:15505067-Retinitis,
pubmed-meshheading:15505067-Vitreous Body
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pubmed:year |
2004
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pubmed:articleTitle |
Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.
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pubmed:affiliation |
Shiley Eye Center, University of California San Diego, La Jolla, California 92093-0946, USA. cheng@eyecenter.ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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