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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-25
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pubmed:abstractText |
Substance P (SP) has memory-promoting, reinforcing and anxiolytic-like effects when applied systemically or centrally. Such effects may be mediated by the neurokinin-1 (NK-1) receptor, since SP preferentially binds to this receptor. We measured the effects of a selective non-peptide NK-1 receptor antagonist, SR140333 (1, 3 and 9 mg/kg i.p.) on ACh levels in frontal cortex, amygdala and hippocampus by microdialysis and HPLC. Levels of ACh in the hippocampus increased dose-dependently immediately after treatment. The same doses of SR140333 given post-trial had minor facilitative effects on inhibitory avoidance learning and open-field habituation, but did not have reinforcing effects in a conditioned place preference (CPP) task. The selective action of NK-1 receptor antagonism on hippocampal ACh may be related to its positive influence on learning.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1959-69
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15501528-Acetylcholine,
pubmed-meshheading:15501528-Amygdala,
pubmed-meshheading:15501528-Animals,
pubmed-meshheading:15501528-Avoidance Learning,
pubmed-meshheading:15501528-Behavior, Animal,
pubmed-meshheading:15501528-Chromatography, High Pressure Liquid,
pubmed-meshheading:15501528-Dose-Response Relationship, Drug,
pubmed-meshheading:15501528-Hippocampus,
pubmed-meshheading:15501528-Injections, Intraperitoneal,
pubmed-meshheading:15501528-Male,
pubmed-meshheading:15501528-Memory,
pubmed-meshheading:15501528-Microdialysis,
pubmed-meshheading:15501528-Piperidines,
pubmed-meshheading:15501528-Quinuclidines,
pubmed-meshheading:15501528-Rats,
pubmed-meshheading:15501528-Rats, Wistar,
pubmed-meshheading:15501528-Receptors, Neurokinin-1,
pubmed-meshheading:15501528-Spatial Behavior,
pubmed-meshheading:15501528-Stereoisomerism
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pubmed:year |
2004
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pubmed:articleTitle |
Neurokinin-1 receptor antagonism by SR140333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects.
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pubmed:affiliation |
Institute of Physiological Psychology, Center for Biological and Medical Research, University of Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany. desouza@uni-desseldorf.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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