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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
43
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pubmed:dateCreated |
2004-10-27
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pubmed:abstractText |
SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE are associated with a high precursor frequency of PLP 139-151-specific T cells in the naive repertoire of SJL mice. To understand the mechanism of EAE resistance in B10.S mice, we determined the precursor frequency of PLP 139-151-reactive T cells in both strains by using IAs/PLP 139-151 tetramers. SJL and B10.S mice had similar frequencies of tetramer-reactive T cells in the naive peripheral repertoire. However, in SJL mice, the majority of PLP 139-151 tetramer-positive cells were in the CD4+CD25- population, whereas there were more tetramer-positive cells in the CD4+CD25+ population of B10.S mice. Depletion of CD4+CD25+ cells in vivo facilitated the expansion of PLP 139-151-reactive cells with production of T helper 1 cytokines in EAE-resistant B10.S mice. Furthermore, anti-CD25 Ab treatment before immunization resulted in EAE induction in these otherwise resistant mice. These data indicate an important role for autoantigen-specific CD4+CD25+ cells in genetic resistance to autoimmunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-10075980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-10464178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-10605010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-10704458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-10850488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-11276194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-11276200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-11390442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-11514600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-12517952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-12522256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-12612581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-12975475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-14530340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-2465343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-6371137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-6806429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-7584131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-8598487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-8757345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-8786337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-9670041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-9712054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15492218-9988264
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15434-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15492218-Amino Acid Sequence,
pubmed-meshheading:15492218-Animals,
pubmed-meshheading:15492218-Antigens, CD4,
pubmed-meshheading:15492218-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:15492218-Genetic Predisposition to Disease,
pubmed-meshheading:15492218-Mice,
pubmed-meshheading:15492218-Molecular Sequence Data,
pubmed-meshheading:15492218-Myelin Proteolipid Protein,
pubmed-meshheading:15492218-Receptors, Interleukin-2
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pubmed:year |
2004
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pubmed:articleTitle |
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.
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pubmed:affiliation |
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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