| pubmed-article:15485630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15485630 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15485630 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:15485630 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:15485630 | lifeskim:mentions | umls-concept:C1699173 | lld:lifeskim |
| pubmed-article:15485630 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15485630 | pubmed:dateCreated | 2004-10-15 | lld:pubmed |
| pubmed-article:15485630 | pubmed:abstractText | For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the expression of alpha4beta7 and CCR9 on T cells upon activation and imprints them with the gut tropism. Dendritic cells from the gut-associated lymphoid organs produced retinoic acid from retinol. The enhanced alpha4beta7 expression on T cells by antigenic stimulation with these dendritic cells was suppressed by the retinal dehydrogenase inhibitor citral and the retinoic acid receptor antagonist LE135. Accordingly, vitamin A deficiency caused a reduction in alpha4beta7(+) memory/activated T cells in lymphoid organs and a depletion of T cells from the intestinal lamina propria. These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells. | lld:pubmed |
| pubmed-article:15485630 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15485630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15485630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15485630 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15485630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15485630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15485630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15485630 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15485630 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:15485630 | pubmed:author | pubmed-author:IwataMakotoM | lld:pubmed |
| pubmed-article:15485630 | pubmed:author | pubmed-author:KagechikaHiro... | lld:pubmed |
| pubmed-article:15485630 | pubmed:author | pubmed-author:KatoChiekoC | lld:pubmed |
| pubmed-article:15485630 | pubmed:author | pubmed-author:SongSi-YoungS... | lld:pubmed |
| pubmed-article:15485630 | pubmed:author | pubmed-author:EshimaYukoY | lld:pubmed |
| pubmed-article:15485630 | pubmed:author | pubmed-author:HirakiyamaAsa... | lld:pubmed |
| pubmed-article:15485630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15485630 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:15485630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15485630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15485630 | pubmed:pagination | 527-38 | lld:pubmed |
| pubmed-article:15485630 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15485630 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15485630 | pubmed:articleTitle | Retinoic acid imprints gut-homing specificity on T cells. | lld:pubmed |
| pubmed-article:15485630 | pubmed:affiliation | Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida-shi, Tokyo 194-8511, Japan. iwata@libra.ls.m-kagaku.co.jp | lld:pubmed |
| pubmed-article:15485630 | pubmed:publicationType | Journal Article | lld:pubmed |
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