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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-10-15
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pubmed:abstractText |
For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the expression of alpha4beta7 and CCR9 on T cells upon activation and imprints them with the gut tropism. Dendritic cells from the gut-associated lymphoid organs produced retinoic acid from retinol. The enhanced alpha4beta7 expression on T cells by antigenic stimulation with these dendritic cells was suppressed by the retinal dehydrogenase inhibitor citral and the retinoic acid receptor antagonist LE135. Accordingly, vitamin A deficiency caused a reduction in alpha4beta7(+) memory/activated T cells in lymphoid organs and a depletion of T cells from the intestinal lamina propria. These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CC chemokine receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/integrin alpha4beta7
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-38
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15485630-Animals,
pubmed-meshheading:15485630-Antineoplastic Agents,
pubmed-meshheading:15485630-Dendritic Cells,
pubmed-meshheading:15485630-Enzyme Inhibitors,
pubmed-meshheading:15485630-Immunohistochemistry,
pubmed-meshheading:15485630-Integrins,
pubmed-meshheading:15485630-Intestinal Mucosa,
pubmed-meshheading:15485630-Intestines,
pubmed-meshheading:15485630-Lymphocyte Activation,
pubmed-meshheading:15485630-Lymphoid Tissue,
pubmed-meshheading:15485630-Mice,
pubmed-meshheading:15485630-Mice, Transgenic,
pubmed-meshheading:15485630-Receptors, CCR,
pubmed-meshheading:15485630-Receptors, Chemokine,
pubmed-meshheading:15485630-Receptors, Lymphocyte Homing,
pubmed-meshheading:15485630-Receptors, Retinoic Acid,
pubmed-meshheading:15485630-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15485630-T-Lymphocytes,
pubmed-meshheading:15485630-Tretinoin,
pubmed-meshheading:15485630-Tropism
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pubmed:year |
2004
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pubmed:articleTitle |
Retinoic acid imprints gut-homing specificity on T cells.
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pubmed:affiliation |
Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida-shi, Tokyo 194-8511, Japan. iwata@libra.ls.m-kagaku.co.jp
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pubmed:publicationType |
Journal Article
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