Linked Life Data

15480180

Source:http://linkedlifedata.com/resource/pubmed/id/15480180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-10-13
pubmed:abstractText
We studied the role of interleukin (IL)-8 during engraftment after hematopoietic stem cell transplantation. In 40 consecutive patients undergoing either allogeneic marrow (n=32) or autologous peripheral blood stem cell transplantation (n=8), IL-8 plasma levels were serially determined. Median IL-8 concentrations peaked during the neutropenic phase and, subsequently, subsided to pretransplant levels in patients achieving engraftment. In all patients, we observed an inverse correlation of IL-8 with leukocytes (P<0.0001) and a direct correlation of IL-8 with the extent of neutropenia (P<0.0001). Four patients who developed graft failure showed sustained median IL-8 concentrations of >300 pg/mL together with persistent neutropenia. This marked elevation of IL-8 was statistically significant as early as day 11 after transplantation, at a time when no other evidence alluded to imminent graft failure. Our data suggest that IL-8 may play an important role during engraftment after hematopoietic stem cell transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1086-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Interleukin-8, neutropenia, and graft failure in human stem cell transplantation.
pubmed:affiliation
Department of Hematology and Oncology, University of Freiburg Medical Center, Hugstetterstrasse, Freiburg, Germany.
pubmed:publicationType
Journal Article