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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2004-10-11
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pubmed:abstractText |
Cisplatin (DDP)-resistant cells commonly exhibit reduced drug accumulation. Previous studies have shown that the major copper (Cu) influx transporter CTR1 controls the uptake of DDP in yeast and mammalian cells. The goal of this study was to examine the effect of Cu and DDP on the level and subcellular localization of hCTR1 protein in human ovarian carcinoma cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6744-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15475465-Antineoplastic Agents,
pubmed-meshheading:15475465-Biological Transport,
pubmed-meshheading:15475465-Blotting, Western,
pubmed-meshheading:15475465-Cation Transport Proteins,
pubmed-meshheading:15475465-Cell Line, Tumor,
pubmed-meshheading:15475465-Cisplatin,
pubmed-meshheading:15475465-Copper,
pubmed-meshheading:15475465-Dose-Response Relationship, Drug,
pubmed-meshheading:15475465-Down-Regulation,
pubmed-meshheading:15475465-Female,
pubmed-meshheading:15475465-Humans,
pubmed-meshheading:15475465-Microscopy, Confocal,
pubmed-meshheading:15475465-Ovarian Neoplasms,
pubmed-meshheading:15475465-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells.
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pubmed:affiliation |
Department of Medicine and the Rebecca and John Moores Cancer Center, University of California at San Diego, La Jolla, California 92093-0058, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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