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rdf:type |
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lifeskim:mentions |
umls-concept:C0003693,
umls-concept:C0021469,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0081408,
umls-concept:C0086418,
umls-concept:C0279628,
umls-concept:C0538927,
umls-concept:C0596263,
umls-concept:C1280500,
umls-concept:C1514559
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pubmed:issue |
19
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pubmed:dateCreated |
2004-10-11
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pubmed:abstractText |
Aberrant arachidonic acid (AA) metabolism, especially through the cyclooxygenase (Cox) and 5-lipoxygenase (5-Lox) pathways, has been suggested to play an important role in the development of esophageal adenocarcinoma (EAC). The purpose of this study was to investigate the expression of 5-Lox in EAC of a rat model and in human samples as well as the chemopreventive effects of zileuton (a specific 5-Lox inhibitor) and celecoxib (a specific Cox2 inhibitor) in the rat EAC model.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BeerDavid GDG,
pubmed-author:ChenXiaoxinX,
pubmed-author:GiordanoThomas JTJ,
pubmed-author:LinYongY,
pubmed-author:LubetRonald ARA,
pubmed-author:ShihWei-Chung JWC,
pubmed-author:SoodSandeepS,
pubmed-author:TanS FSF,
pubmed-author:WangPengP,
pubmed-author:WangSuS,
pubmed-author:WuNanN,
pubmed-author:YangChung SCS
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|
pubmed:issnType |
Print
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pubmed:day |
1
|
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pubmed:volume |
10
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
6703-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15475461-Adenocarcinoma,
pubmed-meshheading:15475461-Anastomosis, Surgical,
pubmed-meshheading:15475461-Animals,
pubmed-meshheading:15475461-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15475461-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:15475461-Body Weight,
pubmed-meshheading:15475461-Dinoprostone,
pubmed-meshheading:15475461-Disease Models, Animal,
pubmed-meshheading:15475461-Dose-Response Relationship, Drug,
pubmed-meshheading:15475461-Drug Therapy, Combination,
pubmed-meshheading:15475461-Esophageal Neoplasms,
pubmed-meshheading:15475461-Humans,
pubmed-meshheading:15475461-Hydroxyurea,
pubmed-meshheading:15475461-Immunohistochemistry,
pubmed-meshheading:15475461-Leukotriene B4,
pubmed-meshheading:15475461-Lipoxygenase Inhibitors,
pubmed-meshheading:15475461-Male,
pubmed-meshheading:15475461-Pyrazoles,
pubmed-meshheading:15475461-Rats,
pubmed-meshheading:15475461-Rats, Sprague-Dawley,
pubmed-meshheading:15475461-Sulfonamides,
pubmed-meshheading:15475461-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis.
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pubmed:affiliation |
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA. xiaochen@rci.rutgers.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
