Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-9-30
pubmed:abstractText
Chronic treatments with antidepressants active on major depressive disorders influence pathways involved in cell survival and plasticity. As astrocytes seem to play a key role in the protection of brain cells, we investigated in these cells the rapid effects of the antidepressant fluoxetine (Prozac) on signaling cascades and gene induction, which probably play a role in neuroprotection. We show here that fluoxetine alone activates the extracellular signal-regulated-protein kinase (Erk) and p38 mitogen-associated protein (MAP) kinase cascades. RT-PCR revealed that genes, modulated in brain by long-term fluoxetine treatment, are rapidly induced by fluoxetine in cultured astrocytes: brain-derived nerve factor (BDNF) and its receptors, glial-derived nerve factor (GDNF) and deiodinase 3 (D3). Induction of D3 by fluoxetine is inhibited by U0126 and SB203580, suggesting that Erk and p38 MAP kinases are involved. Glial-derived nerve factor (GDNF) induction by fluoxetine is prevented by U0126, suggesting that Erk is implicated. Brain-derived nerve factor (BDNF) induction seems mediated by other signaling pathways. In conclusion, we show that fluoxetine alone rapidly activates mitogen activated protein (MAP) kinase cascades in rat astrocytes and that genes involved in neuroprotection are induced in a few hours in a MAP kinase-dependent or -independent manner.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/Fluoxetine, http://linkedlifedata.com/resource/pubmed/chemical/Gdnf protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived..., http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkB, http://linkedlifedata.com/resource/pubmed/chemical/nervous tissue specific protein D3, http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status
MEDLINE
pubmed:issn
0895-8696
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-16
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15456934-Animals, pubmed-meshheading:15456934-Antidepressive Agents, Second-Generation, pubmed-meshheading:15456934-Astrocytes, pubmed-meshheading:15456934-Brain-Derived Neurotrophic Factor, pubmed-meshheading:15456934-Cells, Cultured, pubmed-meshheading:15456934-Enzyme Activation, pubmed-meshheading:15456934-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:15456934-Fluoxetine, pubmed-meshheading:15456934-Gene Expression Regulation, pubmed-meshheading:15456934-Glial Cell Line-Derived Neurotrophic Factor, pubmed-meshheading:15456934-Mitogen-Activated Protein Kinases, pubmed-meshheading:15456934-Nerve Growth Factors, pubmed-meshheading:15456934-Nerve Tissue Proteins, pubmed-meshheading:15456934-Protein-Serine-Threonine Kinases, pubmed-meshheading:15456934-Proto-Oncogene Proteins, pubmed-meshheading:15456934-Proto-Oncogene Proteins c-akt, pubmed-meshheading:15456934-Rats, pubmed-meshheading:15456934-Rats, Sprague-Dawley, pubmed-meshheading:15456934-Receptor, trkB, pubmed-meshheading:15456934-Signal Transduction, pubmed-meshheading:15456934-Transcriptional Activation, pubmed-meshheading:15456934-p38 Mitogen-Activated Protein Kinases
pubmed:year
2004
pubmed:articleTitle
MAP kinase activation by fluoxetine and its relation to gene expression in cultured rat astrocytes.
pubmed:affiliation
Unité de Recherche Stéroïdes et Système Nerveux, Unité 488 de l'Institut National de la Santé et de la Recherche Médicale (INSERM), 94276, Le Kremlin-Bicêtre, France. mercier@kb.inserm.fr
pubmed:publicationType
Journal Article