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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-4-3
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pubmed:databankReference |
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pubmed:abstractText |
Heterotrimeric guanine nucleotide binding proteins transduce signals from cell surface receptors to intracellular effectors. The alpha subunit is believed to confer receptor and effector specificity on the G protein. This role is reflected in the diversity of genes that encode these subunits. The beta and gamma subunits are thought to have a more passive role in G protein function; biochemical data suggests that beta-gamma dimers are shared among the alpha subunits. However, there is growing evidence for active participation of beta-gamma dimers in some G protein mediated signaling systems. To further investigate this role, we examined the diversity of the beta subunit family in mouse. Using the polymerase chain reaction, we uncovered a new member of this family, G beta 4, which is expressed at widely varying levels in a variety of tissues. The predicted amino acid sequence of G beta 4 is 79% to 89% identical to the three previously known beta subunits. The diversity of beta gene products may be an important corollary to the functional diversity of G proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1543505-Amino Acid Sequence,
pubmed-meshheading:1543505-Animals,
pubmed-meshheading:1543505-Base Sequence,
pubmed-meshheading:1543505-Brain Chemistry,
pubmed-meshheading:1543505-GTP-Binding Proteins,
pubmed-meshheading:1543505-Genetic Variation,
pubmed-meshheading:1543505-Mice,
pubmed-meshheading:1543505-Molecular Sequence Data,
pubmed-meshheading:1543505-Protein Conformation,
pubmed-meshheading:1543505-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1543505-Signal Transduction,
pubmed-meshheading:1543505-Tissue Distribution
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pubmed:year |
1992
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pubmed:articleTitle |
Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.
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pubmed:affiliation |
Institut für Entwicklungsbiologie, Universität Köln, FRG.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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