Source:http://linkedlifedata.com/resource/umls/id/C0752348
MSH: GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.,NCI: Heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers, attached to the cell surface plasma membrane, that connect receptors to effectors and thus to intracellular signaling pathways (1). Receptors that couple to G proteins communicate signals from a large number of hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. After the first four G proteins (Gs, Gt, Gi, and Go) were identified by biochemical purification, a large number of G proteins and their subunits were identified by cDNA cloning (2). G proteins consist of three subunits, alpha, beta, and gamma. When signaling, they function