Source:http://linkedlifedata.com/resource/pubmed/id/15380491
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-9-21
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| pubmed:abstractText |
Using a rat formalin-induced conditioned place avoidance (F-CPA) model and Fos immunohistochemistry, the present study observed the effect of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-isoxozole propionic acid/kainite (AMPA/KA) receptors on pain-related aversion. Adult Sprague-Dawley rats were implanted with cannula in the anterior cingulate cortex (ACC) or the lateral ventricle. Before (10 min) the injection of formalin into a hindpaw on days 2 and 4 of place-conditioning trials, vehicle (0.01 M PBS), the NMDA receptors antagonist, 2-amino-5-phosphonovalerate (AP5), or the AMPA/KA receptors antagonist, 6,7-dinitroquinoxaline-2,3-dione (DNQX), was injected through the cannula. F-CPA was effectively eliminated by both intracerebroventricular (icv) and intra-ACC microinjection of AP5. In contrast, the intra-ACC or icv injection of DNQX failed to alter the conditioning scores of F-CPA compared with vehicle control group (P >0.05). Intra-ACC or icv injection of AP5 or DNQX had no effect on formalin-induced acute nociceptive behaviors. Fos immunoreactivity in the ACC was activated by retrieval of pain-related aversion, and this activation was significantly suppressed by preadministration of AP5, but not DNQX (P <0.001). These results suggest that NMDA receptors in the ACC are preferentially involved in the processing of the affective dimension of pain.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0014-4886
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
189
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
413-21
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15380491-Animals,
pubmed-meshheading:15380491-Avoidance Learning,
pubmed-meshheading:15380491-Emotions,
pubmed-meshheading:15380491-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15380491-Glutamic Acid,
pubmed-meshheading:15380491-Gyrus Cinguli,
pubmed-meshheading:15380491-Immunohistochemistry,
pubmed-meshheading:15380491-Male,
pubmed-meshheading:15380491-Nociceptors,
pubmed-meshheading:15380491-Pain,
pubmed-meshheading:15380491-Pain Measurement,
pubmed-meshheading:15380491-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:15380491-Rats,
pubmed-meshheading:15380491-Rats, Sprague-Dawley,
pubmed-meshheading:15380491-Reaction Time,
pubmed-meshheading:15380491-Receptors, AMPA,
pubmed-meshheading:15380491-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:15380491-Synaptic Transmission
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| pubmed:year |
2004
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| pubmed:articleTitle |
NMDA receptors in the anterior cingulate cortex mediate pain-related aversion.
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| pubmed:affiliation |
Institute of Neurobiology, Fudan University, Shanghai 200433, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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